An antiporter (also called exchanger or counter-transporter) is a cotransporter and integral membrane protein involved in secondary active transport of two or more different molecules or ions across a phospholipid membrane such as the plasma membrane in opposite directions. Na+/H+ antiporters have been reviewed.
In secondary active transport, one species of solute moves along its electrochemical gradient, allowing a different species to move against its own electrochemical gradient. This movement is in contrast to primary active transport, in which all solutes are moved against their concentration gradients, fueled by ATP.
Transport may involve one or more of each type of solute. For example, the Na+/Ca2+ exchanger, used by many cells to remove cytoplasmic calcium, exchanges one calcium ion for three sodium ions.
- Padan, Etana; Landau, Meytal (2016). "Chapter 12. Sodium-Proton (Na+/H+) Antiporters:Properties and Roles in Health and Disease". In Astrid, Sigel; Helmut, Sigel; Roland K.O., Sigel. The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences 16. Springer. pp. 391–458. doi:10.1007/978-4-319-21756-7_12.
- Antiporters at the US National Library of Medicine Medical Subject Headings (MeSH)
- Pak, John Edward et al. . Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporte. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18484-9. doi: 10.1073/pnas.1318705110. Epub 2013 Oct 30.
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