Antiprotozoal

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Antiprotozoal agents (ATC code: ATC P01) is a class of pharmaceuticals used in treatment of protozoan infection.

Protozoans have little in common with each other (for example, Entamoeba histolytica, an unikont eukaryotic organism, is less closely related to Naegleria fowleri, a bikont eukaryotic organism, than it is to Homo sapiens, which belongs to the unikont phylogenetic group) and so agents effective against one pathogen may not be effective against another.

They can be grouped by mechanism[1] or by organism.[2] Recent papers have also proposed the use of viruses to treat infections caused by protozoa.[3][4]

Medical Uses[edit]

Antiprotozoals are used to treat protozoal infections, which include amebiasis, giardiasis, cryptosporidiosis, microsporidiosis, Malaria, babesiosis, trypanosomiasis, chaga's disease, leishmaniasis, and toxoplasmosis.[5] Currently, many of the treatments for these infections are limited by their toxicity.[6]

Mechanism[edit]

The mechanisms of antiprotozoal drugs differ significantly drug to drug. For example, it appears that eflornithine, a drug used to treat trypanosomiasis, inhibits ornithine decarboxylase, while the aminoglycoside antibiotic/antiprotozoals used to treat leishmaniasis are thought to inhibit protein synthesis.[7]

Examples[edit]

References[edit]

  1. ^ Cynthia R. L. Webster (15 June 2001). Clinical pharmacology. Teton NewMedia. pp. 86–. ISBN 978-1-893441-37-8. Retrieved 2 May 2010. 
  2. ^ Anthony J. Trevor; Bertram G. Katzung; Susan B. Masters (11 December 2007). Katzung & Trevor's pharmacology: examination & board review. McGraw-Hill Professional. pp. 435–. ISBN 978-0-07-148869-3. Retrieved 2 May 2010. 
  3. ^ Keen, E. C. (2013). "Beyond phage therapy: Virotherapy of protozoal diseases". Future Microbiology. 8 (7): 821–823. doi:10.2217/FMB.13.48. PMID 23841627. 
  4. ^ Hyman, P.; Atterbury, R.; Barrow, P. (2013). "Fleas and smaller fleas: Virotherapy for parasite infections". Trends in Microbiology. 21 (5): 215–220. doi:10.1016/j.tim.2013.02.006. PMID 23540830. 
  5. ^ Khaw, M; Panosian, C B (1 July 1995). "Human antiprotozoal therapy: past, present, and future.". Clinical Microbiology Reviews. 8 (3): 427–439. ISSN 0893-8512. PMC 174634Freely accessible. 
  6. ^ Graebin, C.; Uchoa, F.; Bernardes, L.; Campo, V.; Carvalho, I.; Eifler-Lima, V. (1 October 2009). "Antiprotozoal Agents: An Overview". Anti-Infective Agents in Medicinal Chemistry. 8 (4): 345–366. doi:10.2174/187152109789760199. ISSN 1871-5214. 
  7. ^ CREEK, DARREN J.; BARRETT, MICHAEL P. (9 January 2017). "Determination of antiprotozoal drug mechanisms by metabolomics approaches". Parasitology. 141 (1): 83–92. doi:10.1017/S0031182013000814. ISSN 0031-1820. PMC 3884841Freely accessible.