Antoninus is an Ancient Roman family name which derived from the given name Antonius the Latin form of Anthony.
- Any of the Antonines, including:
- Caracalla (186–217)
- Elagabalus (203-222)
- Antoninus Liberalis, an ancient Greek grammarian who lived between the first and third centuries AD
- Antoninus (philosopher), Neoplatonist philosopher of the 4th century
- Marcus Antoninus (disambiguation), multiple people
- A character from Spartacus (1960 film)
- Antoninus (turncoat), a Roman who joined the Sassanid Empire and assisted Shapur II in the siege of Amida.
- Antonin (disambiguation)
- Antonius, nomen of the gens Antonia, one of the most important plebeian families at Rome
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