|Date of birth||7 April 1988|
|Place of birth||Naples, Italy|
|Height||1.80 m (5 ft 11 in)|
|Playing position||Winger, Striker|
|2008–2009||→ Foggia (loan)||24||(2)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 11 January 2016.
Born in Naples, Campania, Piccolo started his career at Campania club Salernitana Sport. After the club went bankrupt in 2005, he was signed by Serie B club Piacenza. Despite young age, he made his Serie B debut on 8 April 2006 (round 36). He substituted Daniele Degano in added time. That match Piacenza won Brescia 3–1. He played his first start on round 40 (3rd round counted from bottom) which he was replaced by Degano at second half. That match Piacenza lost to Triestina 3–4. He wore no.18 shirt from 2005 to 2008, no.19 in 2009–10 Serie B and no.23 in 2010–11 Serie B.
He was loaned to Lega Pro Prima Divisione club Foggia on 1 September 2008. On 1 July 2009, he returned to Piacenza and made a few substitute appearances. However he was injured, trained separately and returned to the team in March. Piccolo played his first start of the 2010–11 Serie B season on 16 October 2010, as one of the forwards in a 4–3–2–1 formation, partnering with central forward Daniele Cacia and supportive striker Mattia Graffiedi. In that match Piacenza defeated Crotone with the winning goal of Piccolo.
On 31 August 2011 Piccolo was sold to Livorno for €100,000 in co-ownership deal, co-currently Piacenza got half of the registration rights of Francesco Volpe for a peppercorn of €500. After the bankruptcy of Piacenza, Livorno got the full registration rights. Piccolo left for Lanciano in January 2013. In June 2013 Lanciano acquired Piccolo in a new co-ownership deal.
- "Arrivano Ferraro e Rickler" (in Italian). Piacenza Calcio. 1 September 2008. Archived from the original on 21 July 2011. Retrieved 21 October 2010.
- "Piccolo in gruppo". Piacenza Calcio (in Italian). 15 March 2010. Retrieved 21 October 2010.
- "Crotone-Piacenza 0–1". Piacenza Calcio (in Italian). 16 October 2010. Retrieved 21 October 2010.
- AS Livorno Calcio SpA Report and Accounts on 31 December 2012 (Italian)
- "Mercato: Ufficiale il riscatto della metà di Antonio Piccolo: Esercitato il diritto di riscatto del cartellino dal Livorno" (in Italian). SS Virtus Lanciano 1924. 19 June 2013. Retrieved 7 September 2013.