Apoptosis-antagonizing transcription factor

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Apoptosis antagonizing transcription factor
Symbols AATF ; BFR2; CHE-1; CHE1; DED
External IDs OMIM608463 MGI1929608 HomoloGene40811 GeneCards: AATF Gene
Species Human Mouse
Entrez 26574 56321
Ensembl ENSG00000275700 ENSMUSG00000018697
UniProt Q9NY61 Q9JKX4
RefSeq (mRNA) NM_012138 NM_019816
RefSeq (protein) NP_036270 NP_062790
Location (UCSC) Chr 17:
36.95 – 37.06 Mb
Chr 11:
84.42 – 84.51 Mb
PubMed search [1] [2]

Protein AATF is a protein that in humans is encoded by the AATF gene.[1][2][3]

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[3]


Apoptosis-antagonizing transcription factor has been shown to interact with Sp1 transcription factor,[4] POLR2J,[2]PAWR[5] and Retinoblastoma protein.[2][6]


  1. ^ Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Maki M, Kainulainen H (Oct 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochem Biophys Res Commun 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528. 
  2. ^ a b c Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (Jun 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J 14 (7): 904–12. PMID 10783144. 
  3. ^ a b "Entrez Gene: AATF apoptosis antagonizing transcription factor". 
  4. ^ Di Padova, Monica; Bruno Tiziana; De Nicola Francesca; Iezzi Simona; D'Angelo Carmen; Gallo Rita; Nicosia Daniela; Corbi Nicoletta; Biroccio Annamaria; Floridi Aristide; Passananti Claudio; Fanciulli Maurizio (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". J. Biol. Chem. (United States) 278 (38): 36496–504. doi:10.1074/jbc.M306694200. ISSN 0021-9258. PMID 12847090. 
  5. ^ Guo, Qing; Xie Jun (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". J. Biol. Chem. (United States) 279 (6): 4596–603. doi:10.1074/jbc.M309811200. ISSN 0021-9258. PMID 14627703. 
  6. ^ Bruno, Tiziana; De Angelis Roberta; De Nicola Francesca; Barbato Christian; Di Padova Monica; Corbi Nicoletta; Libri Valentina; Benassi Barbara; Mattei Elisabetta; Chersi Alberto; Soddu Silvia; Floridi Aristide; Passananti Claudio; Fanciulli Maurizio (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell (United States) 2 (5): 387–99. doi:10.1016/S1535-6108(02)00182-4. ISSN 1535-6108. PMID 12450794. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.