Applegate is an unincorporated community in Jackson County, Oregon, United States. It is located west of Medford on Oregon Route 238 and the Applegate River. The community was probably named for Lindsay Applegate, who, along with his brothers Jesse and Charles, explored the Applegate Valley while blazing the Applegate Trail.
In 2001, the Applegate Valley AVA became the sixth official wine appellation in Oregon.
This region experiences warm (but not hot) and dry summers, with no average monthly temperatures above 71.6 °F (22.0 °C). According to the Köppen Climate Classification system, Applegate has a warm-summer Mediterranean climate, abbreviated "Csb" on climate maps.