Apramycin

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Apramycin
Apramycin.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
ATCvet code
Identifiers
CAS Number
PubChem CID
DrugBank
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UNII
KEGG
ChEBI
ChEMBL
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ECHA InfoCard100.048.582 Edit this at Wikidata
Chemical and physical data
FormulaC21H41N5O11
Molar mass539.58 g/mol g·mol−1
3D model (JSmol)
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Apramycin (also Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. It is produced by Streptomyces tenebrarius.[1]

Spectrum of bacterial susceptibility and resistance[edit]

Apramycin can be used to treat bacterial infections in animals caused by Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The following shows susceptibility data on medically significant organisms:

  • Escherichia coli - 1 μg/mL - >512 μg/mL (this large range may be due to resistant organisms, typical MIC values are likely in the range of 2 -8 μg/mL.
  • Klebsiella pneumoniae - 2 μg/mL - >256 μg/mL
  • Pseudomonas aeruginosa - 4 μg/mL

[2]

References[edit]

  1. ^ R. Ryden; B. J. Moore (1977). "The in vitro activity of apramycin, a new aminocyditol antibiotic". J Antimicrob Chemother. 3 (6): 609–613. doi:10.1093/jac/3.6.609. PMID 340441.
  2. ^ http://antibiotics.toku-e.com/antimicrobial_1728.html