Apronal

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Apronal
Apronal.svg
Clinical data
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Excretion Renal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.007.677
Chemical and physical data
Formula C9H16N2O2
Molar mass 184.236 g/mol
3D model (JSmol)
Chirality Racemic mixture
  (verify)

Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926[1] by Hoffmann-La Roche that is no longer used, but only used in Japan (See Japanese article). Though it is not a barbiturate, apronalide is similar in structure to the barbiturates (being an open-chain carbamide instead of having a heterocyclic ring).[2] In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours).[2] Upon the finding that it caused patients to develop thrombocytopenic purpura, apronalide was withdrawn from clinical use.[3]

See also[edit]

References[edit]

  1. ^ DE Patent 459903 - Verfahren zur Darstellung von Ureiden der Dialkylessigsaeuren
  2. ^ a b Roche Review .. Hoffman-La Roche, and Roche-organon. 1938. p. 164. 
  3. ^ R. L. Vollum; D. G. Jamison; C. S. Cummins (20 May 2014). Fairbrother's Textbook of Bacteriology. Elsevier Science. pp. 152–. ISBN 978-1-4831-4178-7.