Aquaporin 4

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AQP4
PDB 2d57 EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AQP4, aquaporin 4, HMIWC2, MIWC, WCH4
External IDs OMIM: 600308 MGI: 107387 HomoloGene: 37507 GeneCards: 361
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001650
NM_004028
NM_001317384
NM_001317387

RefSeq (protein)

NP_001641.1
NP_004019.1

Location (UCSC) Chr 18: 26.85 – 26.87 Mb Chr 18: 15.39 – 15.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin 4 also known as AQP4 is a protein which in humans is encoded by the AQP4 gene.[3] AQP4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane.

Function[edit]

AQP4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells.[4]

AQP4 is also expressed in astrocytes and is upregulated by direct insult to the central nervous system.[5]

Pathology[edit]

Aquaporin-4 is the primary autoimmune target in neuromyelitis optica,[6][7] in which AQP4-specific IgG antibodies target astrocytic AQP4, resulting in complement activation and inflammation.[8]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (December 1994). "Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 13052–6. doi:10.1073/pnas.91.26.13052. PMC 45579free to read. PMID 7528931. 
  4. ^ Agre P, Nielsen S (1996). "The aquaporin family of water channels in kidney". Nephrologie. 17 (7): 409–15. PMID 8987045. 
  5. ^ Nagelhus EA, Mathiisen TM, Ottersen OP (2004). "Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1". Neuroscience. 129 (4): 905–13. doi:10.1016/j.neuroscience.2004.08.053. PMID 15561407. 
  6. ^ Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (August 2005). "IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". J. Exp. Med. 202 (4): 473–7. doi:10.1084/jem.20050304. PMC 2212860free to read. PMID 16087714. 
  7. ^ Bradl M, Lassmann DH (September 2008). "Anti-aquaporin-4 antibodies in neuromyelitis optica: how to prove their pathogenetic relevance?" (PDF). International MS Journal / MS Forum. 15 (3): 75–8. PMID 18812056. 
  8. ^ Papadopoulos MC, Bennett JL, Verkman AS (Aug 12, 2014). "Treatment of neuromyelitis optica: state-of-the-art and emerging therapies.". Nature reviews. Neurology. 10: 493–506. doi:10.1038/nrneurol.2014.141. PMID 25112508. 

Further reading[edit]

External links[edit]