Arachidonate—CoA ligase

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arachidonate-CoA ligase
Identifiers
EC number 6.2.1.15
CAS number 82047-87-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an arachidonate-CoA ligase (EC 6.2.1.15) is an enzyme that catalyzes the chemical reaction

ATP + arachidonate + CoA AMP + diphosphate + arachidonoyl-CoA

The 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is arachidonate:CoA ligase (AMP-forming). This enzyme is also called arachidonoyl-CoA synthetase.

References[edit]

  • Wilson DB, Prescott SM, Majerus PW (1982). "Discovery of an arachidonoyl coenzyme A synthetase in human platelets". J. Biol. Chem. 257 (7): 3510–5. PMID 7061494.