In her youth, as one of the few eligible royal princesses from European reigning houses, she was considered an ideal candidate by royal watchers for marriage to Charles, Prince of Wales. Media reports in the 1970s regularly speculated about the prospects of such a marriage, the Daily Express claiming in June 1977 that the couple's engagement was imminent. (Unconfirmed media reports in the British press claimed that Pope Paul VI had prevented a marriage by refusing under Ne Temere to accept that the children of the couple could not be brought up Roman Catholic.)
It has been since suggested that the marriage rumours were a result of efforts to detect a leaker in the Privy Council. In reality, a marriage between the British heir and the Roman Catholic princess was unlikely, as the terms of the Act of Settlement 1701 would have had to have been repealed or modified.
The Archduchess studied in Luxembourg and also in Belgium. She received her diploma as a registered nurse in 1974, and finished her education in 1977, with a nursing certificate in tropical medicine from the Prince Leopold Institute.
She has been the President of the Red Cross for Luxembourg Youth since 1970.
Count Léopold Menno Philippe Gabriel François-Xavier Marie Joseph Ghislain de Limburg-Stirum (b. 19 April 2011).
Count Constantin de Limburg-Stirum (b. 25 October 2013).
Archduke Imre Emanuel Simeon Jean Carl Marcus d'Aviano of Austria (b. 8 December 1985) married on 8 September 2012 Kathleen Elizabeth Walker (b. Cincinnati, Ohio, USA, 1986) in Washington, D.C.. They have a daughter:
Archduchess Maria-Stella Elizabeth Christiana Yolande Alberta of Austria (b. 11 November 2013)
Archduke Christoph Henri Alexander Maria Marcus d'Aviano of Austria (b. Geneva, 2 February 1988), who married Adélaïde Marie Béatrice Drapé-Frisch (b. Lilas, 4 September 1989) on 28 December (civil) and 29 December 2012 (religious) in Nancy. They have a daughter:
Archduchess Katarina Marie-Christine Fabiola of Austria (b. 22 December 2014) 
Archduke Alexander Hector Marie Karl Leopold Marcus d'Aviano of Austria (b. Meyrin, 26 September 1990).
Archduchess Gabriella Maria Pilar Yolande Joséphine Charlotte of Austria (b. Geneva, 26 March 1994).
Archduchess Marie-Astrid and her family live quietly, occasionally appearing at royal weddings and similar events.
17 February 1954 - 6 February 1982: Her Royal Highness Princess Marie-Astrid of Luxembourg, Princess of Nassau, Princess of Bourbon-Parma
6 February 1982 – present: Her Imperial and Royal Highness Archduchess and Princess Imperial Marie-Astrid of Austria, Princess Royal of Hungary and Bohemia, Princess of Luxembourg, Princess of Nassau, Princess of Bourbon-Parma
^Honorary distinctions of the Grand Duchy of Luxembourg, publication of the government of Luxembourg : Princes and Princesses of the Grand-Ducal House of Luxembourg are Grand Crosses of the Order by birth but the decoration is worm only after they reach their majority (18 years old).
* also an infanta of Spain by marriage
** also a princess of Tuscany by marriage
*** also a princess of Modena by marriage
^also an archduchess of Austria in her own right
^^did not have a royal or noble title by birth