Arctiin

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Arctiin
Arctiin.svg
Names
IUPAC name
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-{[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl}oxolan-2-one
Identifiers
20362-31-6 N
ChEMBL ChEMBL388452 YesY
ChemSpider 90827 YesY
Jmol interactive 3D Image
MeSH arctigenin
PubChem 100528
Properties
C27H34O11
Molar mass 534.56 g·mol−1
Melting point 110 to 112 °C (230 to 234 °F; 383 to 385 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Arctiin is a lignan found in many plants of the Asteraceae family, particularly the greater burdock (Arctium lappa) and Centaurea imperialis, and in Trachelospermum asiaticum, Saussurea heteromalla,[1] and Forsythia viridissima.[2] It is the glucoside of arctigenin.

Arctiin and arctigenin have shown anticancer effects in animal research.[citation needed] They have been found to act as agonists of the adiponectin receptor 1.[3]

References[edit]

  1. ^ Arvind Saklani; Manas Ranjan Sahoo; Prabhu Dutt Mishra; Ram Vishwakarma (2010). Indian Journal of Chemistry (PDF) 50B. India: NISCAIR-CSIR. p. 624. ISSN 0975-0983.  Retrieved on April 25, 2011.
  2. ^ David J. Triggle; C. R. Ganellin; F. MacDonald (1996). Dictionary of Pharmacological Agents 1. Boca Raton: Chapman & Hall/CRC. p. 172. ISBN 0-412-46630-9.  Retrieved on September 14, 2008 through Google Book Search.
  3. ^ Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLoS ONE 8 (5): e63354. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032. 

External links[edit]

  • Arctiin entry in the public domain NCI Dictionary of Cancer Terms


 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".