Argemone mexicana

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Argemone mexicana
Argemone mexicana flower 2.jpg
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
Order: Ranunculales
Family: Papaveraceae
Genus: Argemone
Species: A. mexicana
Binomial name
Argemone mexicana
Indian Argemone Mexicana

Argemone mexicana (Mexican poppy,[1] Mexican prickly poppy, flowering thistle,[2] cardo or cardosanto) is a species of poppy found in Mexico and now widely naturalized in many parts of the world. An extremely hardy pioneer plant, it is tolerant of drought and poor soil, often being the only cover on new road cuttings or verges. It has bright yellow latex, and though poisonous to grazing animals, is rarely eaten, but has been used medicinally by many people including those in its native area, the Natives of the western US and parts of Mexico.[3]

Chemical constituents[edit]

A. mexicana seeds contain 22–36% of a pale yellow non-edible oil, called argemone oil or katkar oil, which contains the toxic alkaloids sanguinarine and dihydrosanguinarine. Four quaternary isoquinoline alkaloids, dehydrocorydalmine, jatrorrhizine, columbamine, and oxyberberine, have been isolated from the whole plant of Argemone mexicana.[4]

The seed pods secrete a pale yellow latex when cut open. This argemone resin contains berberine and protopine.


The seeds resemble the seeds of Brassica nigra (mustard). As a result, mustard can be adulterated by argemone seeds, rendering it poisonous. Several significant instances of katkar poisoning have been reported in India, Fiji, South Africa and other countries. The last major outbreak in India occurred in 1998. 1% adulteration of mustard oil by argemone oil has been shown to cause clinical disease.[5]

Katkar oil poisoning causes epidemic dropsy, with symptoms including extreme swelling, particularly of the legs.

Traditional medicine[edit]

The Seri of Sonora, Mexico use the entire plant both fresh and dried. An infusion is made to relieve kidney pain, to help expel a torn placenta, and in general to help cleanse the body after parturition.[3]

When the Spanish arrived in Sonora they added this plant to their pharmacopia and called it cardosanto, which should not be mistranslated to blessed thistle (Cnicus benedictus). Use in Hispanic cultures includes as a sedative and analgesic tea, including for use to help alleviate migraine headaches.[citation needed] The seeds are taken as a laxative.[6]

An Argemone mexicana tea is used by traditional healers in Mali to treat malaria. The whole plant is used to make a tea and as much tea as possible is drunk until symptoms disappear.[7] This use was studied (2010-2012) by doctors Bertrand Graz and Merlin Wilcox, in conjunction with Mali's National Institute of Research in Public Health, using the "reverse pharmacology" methods of Dr. Ashok Vaidya. Before preparing the tea, the toxic seeds were removed to minimize any risk for the patients.[8]

Other uses[edit]

Biodiesel production from A. mexicana seed oil using crystalline manganese carbonate has been demonstrated.[citation needed]


  1. ^ "BSBI List 2007". Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-02-25. Retrieved 2014-10-17. 
  2. ^ Thomas C. Fuller (1986). Poisonous plants of California. University of California Press. pp. 201–. ISBN 978-0-520-05569-8. Retrieved 21 April 2013. 
  3. ^ a b Felger, R. S.; Moser, M. B. (1985). People of the Desert and Sea. Tucson, AZ: University of Arizona Press. 
  4. ^ Singh, S.; Singh, T. D.; Singh, V. P.; Pandey, V. B. (February 2010). "Quaternary Alkaloids of Argemone mexicana". Pharmaceutical Biology 48 (2): 158–160. doi:10.3109/13880200903062622. PMID 20645832. 
  5. ^ "Epidemic dropsy". WHO South East Asia Regional Office. Archived from the original on 31 December 2006. Retrieved 2006-11-17. [dead link]
  6. ^ Moore, M. (1990). Los Remedios: Traditional Herbal Remedies of the Southwest. Santa Fe, NM: Museum of New Mexico Press. 
  7. ^ Willcox, M. L.; Graz, B.; Falquet, J.; et al. (2007). "Argemone mexicana Decoction for the Treatment of Uncomplicated Falciparum Malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene 101 (12): 1190–1198. doi:10.1016/j.trstmh.2007.05.017. PMID 17920092. 
  8. ^ "Drug Developers Take a Second Look at Herbal Medicines". Scientific American. 2014-01-06. 

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