Highway 89's southern terminus is at an intersection with U.S. Route 70 near the western end of Lonoke, Arkansas. From there, it runs 7 miles (11 km) north and west to Furlow then 8½ miles north to Highway 367 at Cabot, Arkansas, the largest city through which the highway runs. Within Cabot, it serves as a portion of two major commercial thoroughfares — first as South Pine Street from city limits into downtown, then turning westward as West Main Street. From Cabot, it runs approximately 6 miles (9.7 km) west crossing Highway 5 at the Pulaski County/ Lonoke County before ending at Highway 107 8 miles (13 km) south of Vilonia, Arkansas.
It resumes again 3½ miles south as Pulaski County Road 89 running west and north 4½ miles to the Faulkner County line where it becomes a state highway again. It continues west 11 more miles intersecting Highway 365 1-mile (1.6 km) north of Mayflower. From there, it travels south 1-mile (1.6 km) then turns west again traveling approximately 5 miles (8.0 km) before continuing as Lollie Road.