|Alma mater||Moscow State University, Russia|
|Known for||Invention of shear-wave elasticity imaging|
|Institutions||Institute of Biophysics of the USSR Academy of Sciences |
Rutgers University, NJ, USA
Artann Laboratories, NJ, USA
Armen Sarvazyan (born July 2, 1939) is a biophysicist and entrepreneur, serving as Chief Science Officer of Artann Laboratories. He is known for his work on the use of shear acoustic waves in medical imaging and diagnostics and the invention of shear-wave elasticity imaging (SWEI).
Sarvazyan received the M.S., Ph.D., and D.Sc. degrees in 1964, 1969, and 1983, respectively, from the Moscow State University, Russia, and Institute of Biophysics of the USSR Academy of Sciences. Early in his career, in the 1960s and 1970s, working in the Institute of Biophysics of the USSR Academy of Sciences in Pushchino, he conducted pioneering studies of propagation of shear waves in soft tissues. A couple of decades later, Sarvazyan proposed a new technology for medical imaging and diagnostics named shear-wave elasticity imaging.
In the 1970s and 1980s, in parallel with the studies of soft tissue biomechanics, he developed ultrasonic devices for the investigation of biomolecular interactions and obtained significant results on thermodynamic characteristics of water in the hydration shell of proteins and nucleic acids.
Beginning in the late 80s, a significant part of Sarvazyan's research activities were on the problems of elastography, an emerging technology of medical diagnostics. In 1991–1992, in collaboration with the University of Michigan, Ann Arbor, Sarvazyan conducted pioneering experiments on MRI and ultrasonic elastography. He published several review papers on biophysical basis of elasticity imaging, on soft tissue biomechanics and on acoustical radiation force, which is currently the key component in the majority of elasticity imaging technologies and devices.
During last decade, most of his research activities and publications were on the various medical applications a branch of elastography called mechanical imaging (a.k.a. tactile imaging), developed by Sarvazyan with Vladimir Egorov.
Sarvazyan has published over 200 research papers and book chapters, and edited 6 books. He has been the Principal Investigator of over 30 research projects funded by NIH, NASA, DoD and Bill and Melinda Gates Foundation. He has over 100 U.S. and international patents and invention certificates.
Sarvazyan is the co-founder of several companies specializing in elastography: ProUroCare Medical Inc.(Golden Valley, MN, 1999), Medical Tactile, Inc. (Los Angeles, CA, 2000), SuperSonic Imagine (Aix-en-Province, France, 2005) and Advanced Tactile Imaging, Inc. (Trenton, NJ, 2013). He is also the founder of Artann Laboratories Inc.
- Sarvazyan AP. Low frequency acoustical characteristics of biological tissues. Mechanics of Polymers 1975; 4: 691-695.
- Sarvazyan AP, Rudenko OV, Swanson SD, Fowlkes JB, Emelianov SY, Shear Wave Elasticity Imaging: A new ultrasonic technology of medical diagnostics. Ultrasound Med. Biol. 1998; 24: 1419-1435.
- Sarvazyan A.P. Ultrasonic velocimetry of biological compounds. Annu. Rev. Biophys. Biophys. Chem. 1991; 20: 321-342.
- Buckin VA, Sarvazyan AP, Kharakoz DP. Water near biological molecules. A review. - In: Water in Disperse Systems. Ed. Deryagin BV, Churaev NV, Ovcharenko D, Moscow, Publ. Chemistry, (in Russian), 1989, 45-63.
- Kharakoz DP, Sarvazyan AP. Hydrational and intrinsic compressibilities of globular proteins. Biopolymers, 1993; 33: 11-26.
- Chalikian TV, Sarvazyan AP, Breslauer KJ. Hydration and compressibility of biological solutes. Biophys. Chem. 1994; 51: 89-109.
- Fowlkes J, Emelianov S, Pipe J, Carson P, Adler R, Sarvazyan A, Skovoroda A. Possibility of cancer detection through measurement of elasticity properties. Radiology 1992; 185(P): 206-207.
- Sarvazyan AP, Skovoroda AR, Emelianov SY, Fowlkes JB, Pipe JG, Adler RS, Buxton RB, Carson PL. Biophysical bases of elasticity imaging. In: Acoustical Imaging. Ed. Jones JP, Plenum Press, New York and London, 1995; 21: 223-240.
- Fowlkes JB, Emelianov SY, Pipe JG, Skovoroda AR, Carson PL, Adler RS, and Sarvazyan AP, Magnetic-resonance imaging techniques for detection of elasticity variation. Med Phys, 1995; 22(11): 1771-8.
- Sarvazyan AP. Elastic properties of soft tissues. In: Handbook of Elastic Properties of Solids, Liquids and Gases, Volume III, Chapter 5, eds. Levy M, Bass HE and Stern RR, Academic Press, New York 2001, 107-127.
- Sarvazyan A, Hill CR. Physical chemistry of the ultrasound-tissue interaction. In: Physical Principles of Medical Ultrasonics. 2nd ed. Chichester: John Wiley, Chapter 7, eds. Hill CR, Bamber JC, ter Haar GR, 2004, 223-235.
- Sarvazyan AP, Rudenko OV, Nyborg WL. Biomedical applications of radiation force of ultrasound: Historical roots and physical basis. Review. Ultrasound in Medicine and Biology 2010; 36(9): 1379-1394.
- Sarvazyan A. Diversity of biomedical applications of acoustic radiation force. Review. Ultrasonics 2010, 50(2):230-4.
- Sarvazyan A, Hall TJ, Urban MW, Fatemi M, Aglyamov SR, Garra BS. An overview of Elastography–an emerging branch of medical imaging. Current Medical Imaging Reviews, 2011, 7(4):255-282.
- Sarvazyan AP. Mechanical imaging: a new technology for medical diagnostics. Int. J. Med. Inf. 1998; 49: 195-216.
- Sarvazyan A, Egorov V, and Sarvazyan N. Tactile sensing and tactile imaging in detection of cancer, book chapter In: Biosensors and Molecular Technologies for Cancer Diagnostics, ed. Keith E. Harold, CRC Press, May 29, 2012, 339-354.
- Sarvazyan A, Egorov V. Mechanical Imaging – a technology for 3-D visualization and characterization of soft tissue abnormalities: a review. Current Medical Imaging Reviews, 2012, 8(1):64-73.