Artificial intelligence in healthcare
Artificial intelligence in healthcare is an overarching term used to describe the use of machine-learning algorithms and software, or artificial intelligence (AI), to mimic human cognition in the analysis, presentation, and comprehension of complex medical and health care data. Specifically, AI is the ability of computer algorithms to approximate conclusions based solely on input data.
The primary aim of health-related AI applications is to analyze relationships between clinical techniques and patient outcomes. AI programs are applied to practices such as diagnostics, treatment protocol development, drug development, personalized medicine, and patient monitoring and care. What differentiates AI technology from traditional technologies in healthcare is the ability to gather data, process it, and produce a well-defined output to the end-user. AI does this through machine learning algorithms and deep learning. These processes can recognize patterns in behavior and create their own logic. To gain useful insights and predictions, machine learning models must be trained using extensive amounts of input data. AI algorithms behave differently from humans in two ways: (1) algorithms are literal: once a goal is set, the algorithm learns exclusively from the input data and can only understand what it has been programmed to do, (2) and some deep learning algorithms are black boxes; algorithms can predict with extreme precision, but offer little to no comprehensible explanation to the logic behind its decisions aside from the data and type of algorithm used.
As widespread use of AI in healthcare is relatively new, research is ongoing into its application in various fields of medicine and industry. Additionally, greater consideration is being given to the unprecedented ethical concerns related to its practice such as data privacy, automation of jobs, and representation biases.
Research in the 1960s and 1970s produced the first problem-solving program, or expert system, known as Dendral. While it was designed for applications in organic chemistry, it provided the basis for a subsequent system MYCIN, considered one of the most significant early uses of artificial intelligence in medicine. MYCIN and other systems such as INTERNIST-1 and CASNET did not achieve routine use by practitioners, however.
The 1980s and 1990s brought the proliferation of the microcomputer and new levels of network connectivity. During this time, there was a recognition by researchers and developers that AI systems in healthcare must be designed to accommodate the absence of perfect data and build on the expertise of physicians. Approaches involving fuzzy set theory, Bayesian networks, and artificial neural networks, have been applied to intelligent computing systems in healthcare.
Medical and technological advancements occurring over this half-century period that have enabled the growth of healthcare-related applications of AI to include:
- Improvements in computing power resulting in faster data collection and data processing
- Growth of genomic sequencing databases
- Widespread implementation of electronic health record systems
- Improvements in natural language processing and computer vision, enabling machines to replicate human perceptual processes
- Enhanced the precision of robot-assisted surgery
- Improvements in deep learning techniques and data logs in rare diseases
AI algorithms can also be used to analyze large amounts of data through electronic health records for disease prevention and diagnosis. Medical institutions such as The Mayo Clinic, Memorial Sloan Kettering Cancer Center, and the British National Health Service, have developed AI algorithms for their departments. Large technology companies such as IBM and Google, have also developed AI algorithms for healthcare. Additionally, hospitals are looking to AI software to support operational initiatives that increase cost saving, improve patient satisfaction, and satisfy their staffing and workforce needs. Currently, the United States government is investing billions of dollars to progress the development of AI in healthcare. Companies are developing technologies that help healthcare managers improve business operations through increasing utilization, decreasing patient boarding, reducing length of stay and optimizing staffing levels.
Artificial intelligence algorithms have shown promising results in accurately diagnosing and risk stratifying patients with concern for coronary artery disease, showing potential as an initial triage tool, though few studies have directly compared the accuracy of machine learning models to clinician diagnostic ability. Other algorithms have been used in predicting patient mortality, medication effects, and adverse events following treatment for acute coronary syndrome. Wearables, smartphones, and internet-based technologies have also shown the ability to monitor patients' cardiac data points, expanding the amount of data and the various settings AI models can use and potentially enabling earlier detection of cardiac events occurring outside of the hospital. Another growing area of research is the utility of AI in classifying heart sounds and diagnosing valvular disease. Challenges of AI in cardiovascular medicine have included the limited data available to train machine learning models, such as limited data on social determinants of health as they pertain to cardiovascular disease.
Dermatology is an imaging abundant speciality and the development of deep learning has been strongly tied to image processing. Therefore, there is a natural fit between the dermatology and deep learning. There are 3 main imaging types in dermatology: contextual images, macro images, micro images. For each modality, deep learning showed great progress. Han et al. showed keratinocytic skin cancer detection from face photographs. Esteva et al. demonstrated dermatologist-level classification of skin cancer from lesion images. Noyan et al. demonstrated a convolutional neural network that achieved 94% accuracy at identifying skin cells from microscopic Tzanck smear images.
Recent advances have suggested the use of AI to describe and evaluate the outcome of maxillo-facial surgery or the assessment of cleft palate therapy in regard to facial attractiveness or age appearance.
In 2018, a paper published in the journal Annals of Oncology mentioned that skin cancer could be detected more accurately by an artificial intelligence system (which used a deep learning convolutional neural network) than by dermatologists. On average, the human dermatologists accurately detected 86.6% of skin cancers from the images, compared to 95% for the CNN machine.
AI can play a role in various facets of the field of gastroenterology. Endoscopic exams such as esophagogastroduodenoscopies (EGD) and colonoscopies rely on rapid detection of abnormal tissue. By enhancing these endoscopic procedures with AI, clinicians can more rapidly identify diseases, determine their severity, and visualize blind spots. Early trials in using AI detection systems of early gastric cancer have shown sensitivity close to expert endoscopists.
AI has shown potential in both the laboratory and clinical spheres of infectious disease medicine. As the novel coronavirus ravages through the globe, the United States is estimated to invest more than $2 billion in AI-related healthcare research by 2025, more than 4 times the amount spent in 2019 ($463 million). Neural networks have been developed to rapidly and accurately detect a host response to COVID-19 from mass spectrometry samples. Other applications include support-vector machines identifying antimicrobial resistance, machine learning analysis of blood smears to detect malaria, and improved point-of-care testing of Lyme disease based on antigen detection. Additionally, AI has been investigated for improving diagnosis of meningitis, sepsis, and tuberculosis, as well as predicting treatment complications in hepatitis B and hepatitis C patients.
AI has been explored for use in cancer diagnosis, risk stratification, molecular characterization of tumors, and cancer drug discovery. A particular challenge in oncologic care that AI is being developed to address is the ability to accurately predict which treatment protocols will be best suited for each patient based on their individual genetic, molecular, and tumor-based characteristics. Through its ability to translate images to mathematical sequences, AI has been trialed in cancer diagnostics with the reading of imaging studies and pathology slides. In January 2020, researchers demonstrated an AI system, based on a Google DeepMind algorithm, capable of surpassing human experts in breast cancer detection. In July 2020, it was reported that an AI algorithm developed by the University of Pittsburgh achieves the highest accuracy to date in identifying prostate cancer, with 98% sensitivity and 97% specificity.
For many diseases, pathological analysis of cells and tissues is considered to be the gold standard of disease diagnosis. AI-assisted pathology tools have been developed to assist with the diagnosis of a number of diseases, including hepatitis B, gastric cancer, and colorectal cancer. AI has also been used to predict genetic mutations and prognosticate disease outcomes. AI is well-suited for use in low-complexity pathological analysis of large-scale screening samples, such as colorectal or breast cancer screening, thus lessening the burden on pathologists and allowing for faster turnaround of sample analysis. Several deep learning and artificial neural network models have shown accuracy similar to that of human pathologists, and a study of deep learning assistance in diagnosing metastatic breast cancer in lymph nodes showed that the accuracy of humans with the assistance of a deep learning program was higher than either the humans alone or the AI program alone. Additionally, implementation of digital pathology is predicted to save over $12 million for a university center over the course of five years, though savings attributed to AI specifically have not yet been widely researched. The use of augmented and virtual reality could prove to be a stepping stone to wider implementation of AI-assisted pathology, as they can highlight areas of concern on a pathology sample and present them in real-time to a pathologist for more efficient review. AI also has the potential to identify histological findings at levels beyond what the human eye can see, and has shown the ability to utilize genotypic and phenotypic data to more accurately detect the tumor of origin for metastatic cancer. One of the major current barriers to widespread implementation of AI-assisted pathology tools is the lack of prospective, randomized, multi-center controlled trials in determining the true clinical utility of AI for pathologists and patients, highlighting a current area of need in AI and healthcare research.
Primary care has become one key development area for AI technologies. AI in primary care has been used for supporting decision making, predictive modelling, and business analytics. Despite the rapid advances in AI technologies, general practitioners' view on the role of AI in primary care is very limited–mainly focused on administrative and routine documentation tasks. There are only few examples of AI decision support systems that were prospectively assessed on clinical efficacy when used in practice by physicians. But there are cases where the use of these systems yielded a positive effect on treatment choice by physicians.
In psychiatry, AI applications are still in a phase of proof-of-concept. Areas where the evidence is widening quickly include predictive modelling of diagnosis and treatment outcomes, chatbots, conversational agents that imitate human behaviour and which have been studied for anxiety and depression.
Challenges include the fact that many applications in the field are developed and proposed by private corporations, such as the screening for suicidal ideation implemented by Facebook in 2017. Such applications outside the healthcare system raise various professional, ethical and regulatory questions. Another issue is often with the validity and interpretabiltiy of the models. Small training datasets contain bias that is inherited by the models, and compromises the generalizability and stability of these models. Such models may also have the potential to be discriminatory against minority groups that are underrepresented in samples.
AI is being studied within the field of radiology to detect and diagnose diseases through Computerized Tomography (CT) and Magnetic Resonance (MR) Imaging. It may be particularly useful in settings where demand for human expertise exceeds supply, or where data is too complex to be efficiently interpreted by human readers. Several deep learning models have shown the capability to be roughly as accurate as healthcare professionals in identifying diseases through medical imaging, though few of the studies reporting these findings have been externally validated. AI can also provide non-interpretive benefit to radiologists, such as reducing noise in images, creating high-quality images from lower doses of radiation, enhancing MR image quality, and automatically assessing image quality. Further research investigating the use of AI in nuclear medicine focuses on image reconstruction, anatomical landmarking, and the enablement of lower doses in imaging studies.
An article by Jiang, et al. (2017) demonstrated that there are several types of AI techniques that have been used for a variety of different diseases, such as support vector machines, neural networks, and decision trees. Each of these techniques is described as having a “training goal” so “classifications agree with the outcomes as much as possible…”.
To demonstrate some specifics for disease diagnosis/classification there are two different techniques used in the classification of these diseases include using “Artificial Neural Networks (ANN) and Bayesian Networks (BN)”. It was found that ANN was better and could more accurately classify diabetes and CVD.
Through the use of Medical Learning Classifiers (MLC's), Artificial Intelligence has been able to substantially aid doctors in patient diagnosis through the manipulation of mass Electronic Health Records (EHR's). Medical conditions have grown more complex, and with a vast history of electronic medical records building, the likelihood of case duplication is high. Although someone today with a rare illness is less likely to be the only person to have suffered from any given disease, the inability to access cases from similarly symptomatic origins is a major roadblock for physicians. The implementation of AI to not only help find similar cases and treatments, but also factor in chief symptoms and help the physicians ask the most appropriate questions helps the patient receive the most accurate diagnosis and treatment possible.
The increase of telemedicine, the treatment of patients remotely, has shown the rise of possible AI applications. AI can assist in caring for patients remotely by monitoring their information through sensors. A wearable device may allow for constant monitoring of a patient and the ability to notice changes that may be less distinguishable by humans. The information can be compared to other data that has already been collected using artificial intelligence algorithms that alert physicians if there are any issues to be aware of.
Another application of artificial intelligence is chat-bot therapy. Some researchers charge that the reliance on chatbots for mental healthcare does not offer the reciprocity and accountability of care that should exist in the relationship between the consumer of mental healthcare and the care provider (be it a chat-bot or psychologist), though.
Since the average age has risen due to a longer life expectancy, artificial intelligence could be useful in helping take care of older populations. Tools such as environment and personal sensors can identify a person's regular activities and alert a caretaker if a behavior or a measured vital is abnormal. Although the technology is useful, there are also discussions about limitations of monitoring in order to respect a person's privacy since there are technologies that are designed to map out home layouts and detect human interactions.
Electronic health records
Electronic health records (EHR) are crucial to the digitalization and information spread of the healthcare industry. Now that around 80% of medical practices use EHR, the next step is to use artificial intelligence to interpret the records and provide new information to physicians.
One application uses natural language processing (NLP) to make more succinct reports that limit the variation between medical terms by matching similar medical terms. For example, the term heart attack and myocardial infarction mean the same things, but physicians may use one over the over based on personal preferences. NLP algorithms consolidate these differences so that larger datasets can be analyzed. Another use of NLP identifies phrases that are redundant due to repetition in a physician's notes and keeps the relevant information to make it easier to read. Other applications use concept processing to analyze the information entered by the current patient's doctor to present similar cases and help the physician remember to include all relevant details.
Beyond making content edits to an EHR, there are AI algorithms that evaluate an individual patient's record and predict a risk for a disease based on their previous information and family history. One general algorithm is a rule-based system that makes decisions similarly to how humans use flow charts. This system takes in large amounts of data and creates a set of rules that connect specific observations to concluded diagnoses. Thus, the algorithm can take in a new patient's data and try to predict the likeliness that they will have a certain condition or disease. Since the algorithms can evaluate a patient's information based on collective data, they can find any outstanding issues to bring to a physician's attention and save time. One study conducted by the Centerstone research institute found that predictive modeling of EHR data has achieved 70–72% accuracy in predicting individualized treatment response. These methods are helpful due to the fact that the amount of online health records doubles every five years. Physicians do not have the bandwidth to process all this data manually, and AI can leverage this data to assist physicians in treating their patients.
Improvements in natural language processing led to the development of algorithms to identify drug-drug interactions in medical literature. Drug-drug interactions pose a threat to those taking multiple medications simultaneously, and the danger increases with the number of medications being taken. To address the difficulty of tracking all known or suspected drug-drug interactions, machine learning algorithms have been created to extract information on interacting drugs and their possible effects from medical literature. Efforts were consolidated in 2013 in the DDIExtraction Challenge, in which a team of researchers at Carlos III University assembled a corpus of literature on drug-drug interactions to form a standardized test for such algorithms. Competitors were tested on their ability to accurately determine, from the text, which drugs were shown to interact and what the characteristics of their interactions were. Researchers continue to use this corpus to standardize the measurement of the effectiveness of their algorithms.
Other algorithms identify drug-drug interactions from patterns in user-generated content, especially electronic health records and/or adverse event reports. Organizations such as the FDA Adverse Event Reporting System (FAERS) and the World Health Organization's VigiBase allow doctors to submit reports of possible negative reactions to medications. Deep learning algorithms have been developed to parse these reports and detect patterns that imply drug-drug interactions.
Creation of new drugs
DSP-1181, a molecule of the drug for OCD (obsessive-compulsive disorder) treatment, was invented by artificial intelligence through joint efforts of Exscientia (British start-up) and Sumitomo Dainippon Pharma (Japanese pharmaceutical firm). The drug development took a single year, while pharmaceutical companies usually spend about five years on similar projects. DSP-1181 was accepted for a human trial.
In September 2019 Insilico Medicine reports the creation, via artificial intelligence, of six novel inhibitors of the DDR1 gene, a kinase target implicated in fibrosis and other diseases. The system, known as Generative Tensorial Reinforcement Learning (GENTRL), designed the new compounds in 21 days, with a lead candidate tested and showing positive results in mice.
The same month Canadian company Deep Genomics announces that its AI-based drug discovery platform has identified a target and drug candidate for Wilson's disease. The candidate, DG12P1, is designed to correct the exon-skipping effect of Met645Arg, a genetic mutation affecting the ATP7B copper-binding protein.
The trend of large health companies merging allows for greater health data accessibility. Greater health data lays the groundwork for the implementation of AI algorithms.
A large part of industry focus of implementation of AI in the healthcare sector is in the clinical decision support systems. As more data is collected, machine learning algorithms adapt and allow for more robust responses and solutions. Numerous companies are exploring the possibilities of the incorporation of big data in the healthcare industry. Many companies investigate the market opportunities through the realms of “data assessment, storage, management, and analysis technologies” which are all crucial parts of the healthcare industry.
The following are examples of large companies that have contributed to AI algorithms for use in healthcare:
- IBM's Watson Oncology is in development at Memorial Sloan Kettering Cancer Center and Cleveland Clinic. IBM is also working with CVS Health on AI applications in chronic disease treatment and with Johnson & Johnson on analysis of scientific papers to find new connections for drug development. In May 2017, IBM and Rensselaer Polytechnic Institute began a joint project entitled Health Empowerment by Analytics, Learning and Semantics (HEALS), to explore using AI technology to enhance healthcare.
- Microsoft's Hanover project, in partnership with Oregon Health & Science University's Knight Cancer Institute, analyzes medical research to predict the most effective cancer drug treatment options for patients. Other projects include medical image analysis of tumor progression and the development of programmable cells.
- Google's DeepMind platform is being used by the UK National Health Service to detect certain health risks through data collected via a mobile app. A second project with the NHS involves the analysis of medical images collected from NHS patients to develop computer vision algorithms to detect cancerous tissues.
- Tencent is working on several medical systems and services. These include AI Medical Innovation System (AIMIS), an AI-powered diagnostic medical imaging service; WeChat Intelligent Healthcare; and Tencent Doctorwork
- Intel's venture capital arm Intel Capital recently invested in startup Lumiata which uses AI to identify at-risk patients and develop care options.
- Neuralink has come up with a next-generation neuroprosthetic which intricately interfaces with thousands of neural pathways in the brain. Their process allows a chip, roughly the size of a quarter, to be inserted in the place of a chunk of a skull by a precision surgical robot to avoid accidental injury .
Digital consultant apps like use AI to give medical consultation based on personal medical history and common medical knowledge. Users report their symptoms into the app, which uses speech recognition to compare against a database of illnesses. Babylon then offers a recommended action, taking into account the user's medical history. Entrepreneurs in healthcare have been effectively using seven business model archetypes to take AI solution[buzzword] to the marketplace. These archetypes depend on the value generated for the target user (e.g. patient focus vs. healthcare provider and payer focus) and value capturing mechanisms (e.g. providing information or connecting stakeholders).
IFlytek launched a service robot “Xiao Man”, which integrated artificial intelligence technology to identify the registered customer and provide personalized recommendations in medical areas. It also works in the field of medical imaging. Similar robots are also being made by companies such as UBTECH ("Cruzr") and Softbank Robotics ("Pepper").
With the market for AI expanding constantly, large tech companies such as Apple, Google, Amazon, and Baidu all have their own AI research divisions, as well as millions of dollars allocated for acquisition of smaller AI based companies. Many automobile manufacturers are beginning to use machine learning healthcare in their cars as well. Companies such as BMW, GE, Tesla, Toyota, and Volvo all have new research campaigns to find ways of learning a driver's vital statistics to ensure they are awake, paying attention to the road, and not under the influence of substances or in emotional distress.
Expanding care to developing nations
Artificial intelligence continues to expand in its abilities to diagnose more people accurately in nations where fewer doctors are accessible to the public. Many new technology companies such as SpaceX and the Raspberry Pi Foundation have enabled more developing countries to have access to computers and the internet than ever before. With the increasing capabilities of AI over the internet, advanced machine learning algorithms can allow patients to get accurately diagnosed when they would previously have no way of knowing if they had a life-threatening disease or not.
Using AI in developing nations who do not have the resources will diminish the need for outsourcing and can improve patient care. AI can allow for not only diagnosis of patient is areas where healthcare is scarce, but also allow for a good patient experience by resourcing files to find the best treatment for a patient. The ability of AI to adjust course as it goes also allows the patient to have their treatment modified based on what works for them; a level of individualized care that is nearly non-existent in developing countries.
While research on the use of AI in healthcare aims to validate its efficacy in improving patient outcomes before its broader adoption, its use may nonetheless introduce several new types of risk to patients and healthcare providers, such as algorithmic bias, Do not resuscitate implications, and other machine morality issues. These challenges of the clinical use of AI has brought upon potential need for regulations.
Currently, there are regulations pertaining to the collection of patient data. This includes policies such as the Health Insurance Portability and Accountability Act (HIPAA) and the European General Data Protection Regulation (GDPR). The GDPR pertains to patients within the EU and details the consent requirements for patient data use when entities collect patient healthcare data. Similarly, HIPAA protects healthcare data from patient records in the United States. In May 2016, the White House announced its plan to host a series of workshops and formation of the National Science and Technology Council (NSTC) Subcommittee on Machine Learning and Artificial Intelligence. In October 2016, the group published The National Artificial Intelligence Research and Development Strategic Plan, outlining its proposed priorities for Federally-funded AI research and development (within government and academia). The report notes a strategic R&D plan for the subfield of health information technology is in development stages.
The only agency that has expressed concern is the FDA. Bakul Patel, the Associate Center Director for Digital Health of the FDA, is quoted saying in May 2017:
“We're trying to get people who have hands-on development experience with a product's full life cycle. We already have some scientists who know artificial intelligence and machine learning, but we want complementary people who can look forward and see how this technology will evolve.”
The joint ITU-WHO Focus Group on Artificial Intelligence for Health (FG-AI4H) has built a platform for the testing and benchmarking of AI applications in health domain. As of November 2018, eight use cases are being benchmarked, including assessing breast cancer risk from histopathological imagery, guiding anti-venom selection from snake images, and diagnosing skin lesions.
In January 2021, the FDA published a new Action Plan, entitled Artificial Intelligence/Machine Learning[AI/ML]-Based Software as a Medical Device [SaMD] Action Plan. This plan lays out the FDA’s future plans for regulation of medical devices that would include artificial intelligence in their software. There are five main actions the FDA plans to take to increase regulation: 1. Tailored Regulatory Framework for Ai/M:-based SaMD, 2. Good Machine Learning Practice (GMLP), 3. Patient-Centered Approach Incorporating Transparency to Users, 4. Regulatory Science Methods Related to Algorithm Bias & Robustness, and 5. Real-World Performance(RWP). This plan was in direct response to stakeholders’ feedback on a 2019 discussion paper also published by the FDA.
In order to effectively train Machine Learning and use AI in healthcare, massive amounts of data must be gathered. Acquiring this data, however, comes at the cost of patient privacy in most cases and is not well received publicly. For example, a survey conducted in the UK estimated that 63% of the population is uncomfortable with sharing their personal data in order to improve artificial intelligence technology. The scarcity of real, accessible patient data is a hindrance that deters the progress of developing and deploying more artificial intelligence in healthcare.
According to a recent study, AI can replace up to 35% of jobs in the UK within the next 10 to 20 years. However, of these jobs, it was concluded that AI has not eliminated any healthcare jobs so far. Though if AI were to automate healthcare related jobs, the jobs most susceptible to automation would be those dealing with digital information, radiology, and pathology, as opposed to those dealing with doctor to patient interaction.
Automation can provide benefits alongside doctors as well. It is expected that doctors who take advantage of AI in healthcare will provide greater quality healthcare than doctors and medical establishments who do not. AI will likely not completely replace healthcare workers but rather give them more time to attend to their patients. AI may avert healthcare worker burnout and cognitive overload
AI will ultimately help contribute to progression of societal goals which include better communication, improved quality of healthcare, and autonomy.
Since AI makes decisions solely on the data it receives as input, it is important that this data represents accurate patient demographics. In a hospital setting, patients do not have full knowledge of how predictive algorithms are created or calibrated. Therefore, these medical establishments can unfairly code their algorithms to discriminate against minorities and prioritize profits rather than providing optimal care.
There can also be unintended bias in these algorithms that can exacerbate social and healthcare inequities. Since AI's decisions are a direct reflection of its input data, the data it receives must have accurate representation of patient demographics. White males are overly represented in medical data sets. Therefore, having minimal patient data on minorities can lead to AI making more accurate predictions for majority populations, leading to unintended worse medical outcomes for minority populations. Collecting data from minority communities can also lead to medical discrimination. For instance, HIV is a prevalent virus among minority communities and HIV status can be used to discriminate against patients. In addition to biases that may arise from sample selection, different clinical systems used to collect data may also impact AI functionality. For example, radiographic systems and their outcomes (e.g., resolution) vary by provider. Moreover, clinician work practices, such as the positioning of the patient for radiography, can also greatly influence the data and make comparability difficult. However, these biases are able to be eliminated through careful implementation and a methodical collection of representative data.
- Artificial intelligence
- Glossary of artificial intelligence
- Full body scanner (i.e. Dermascanner, ...)
- Clinical decision support system
- Computer-aided diagnosis
- Computer-aided simple triage
- Google DeepMind
- IBM Watson Health
- Medical image computing
- Michal Rosen-Zvi
- Speech recognition software in healthcare
- The MICCAI Society
- Coiera E (1997). Guide to medical informatics, the Internet and telemedicine. Chapman & Hall, Ltd.
- Luca M, Kleinberg J, Mullainathan S (January–February 2016). "Algorithms Need Managers, Too". Harvard Business Review. Retrieved 2018-10-08.
- Floridi, Luciano; Luetge, Christoph; Pagallo, Ugo; Schafer, Burkhard; Valcke, Peggy; Vayena, Effy; Addison, Janet; Hughes, Nigel; Lea, Nathan; Sage, Caroline; Vannieuwenhuyse, Bart (2019-09-01). "Key Ethical Challenges in the European Medical Information Framework". Minds and Machines. 29 (3): 355–371. doi:10.1007/s11023-018-9467-4. ISSN 1572-8641. S2CID 49668711.
- Lindsay RK, Buchanan BG, Feigenbaum EA, Lederberg J (1993). "DENDRAL: a case study of the first expert system for scientific hypothesis formation". Artificial Intelligence. 61 (2): 209–261. doi:10.1016/0004-3702(93)90068-m. hdl:2027.42/30758.
- Clancey WJ, Shortliffe EH (1984). Readings in medical artificial intelligence: the first decade. Addison-Wesley Longman Publishing Co., Inc.
- Bruce G, Buchanan BG, Shortliffe ED (1984). Rule-based expert systems: the MYCIN experiments of the Stanford Heuristic Programming Project.
- Duda RO, Shortliffe EH (April 1983). "Expert Systems Research". Science. 220 (4594): 261–8. Bibcode:1983Sci...220..261D. doi:10.1126/science.6340198. PMID 6340198.
- Miller RA (1994). "Medical diagnostic decision support systems--past, present, and future: a threaded bibliography and brief commentary". Journal of the American Medical Informatics Association. 1 (1): 8–27. doi:10.1136/jamia.1994.95236141. PMC 116181. PMID 7719792.
- Adlassnig KP (July 1980). "A fuzzy logical model of computer-assisted medical diagnosis" (PDF). Methods of Information in Medicine. 19 (3): 141–8. doi:10.1055/s-0038-1636674. PMID 6997678.
- Reggia JA, Peng Y (September 1987). "Modeling diagnostic reasoning: a summary of parsimonious covering theory". Computer Methods and Programs in Biomedicine. 25 (2): 125–34. doi:10.1016/0169-2607(87)90048-4. PMC 2244953. PMID 3315427.
- Baxt WG (December 1991). "Use of an artificial neural network for the diagnosis of myocardial infarction". Annals of Internal Medicine. 115 (11): 843–8. doi:10.7326/0003-4819-115-11-843. PMID 1952470.
- Maclin PS, Dempsey J, Brooks J, Rand J (February 1991). "Using neural networks to diagnose cancer". Journal of Medical Systems. 15 (1): 11–9. doi:10.1007/bf00993877. PMID 1748845. S2CID 10189561.
- Koomey J, Berard S, Sanchez M, Wong H (March 2010). "Implications of historical trends in the electrical efficiency of computing". IEEE Annals of the History of Computing. 33 (3): 46–54. CiteSeerX 10.1.1.323.9505. doi:10.1109/MAHC.2010.28. S2CID 8305701.
- Barnes B, Dupré J (2009). Genomes and what to make of them. University of Chicago Press.[page needed]
- Jha AK, DesRoches CM, Campbell EG, Donelan K, Rao SR, Ferris TG, et al. (April 2009). "Use of electronic health records in U.S. hospitals". The New England Journal of Medicine. 360 (16): 1628–38. doi:10.1056/NEJMsa0900592. PMID 19321858. S2CID 19914056.
- Banko M, Brill E (July 2001). "Scaling to very very large corpora for natural language disambiguation]" (PDF). Proceedings of the 39th Annual Meeting on Association for Computational Linguistics. Association for Computational Linguistics: 26–33. Archived from the original (PDF) on 2019-04-07. Retrieved 2019-04-07.
- Dougherty G (2009). Digital image processing for medical applications. Cambridge University Press.
- "Artificial Intelligence and Machine Learning for Healthcare". Sigmoidal. 21 December 2017. Archived from the original on 17 August 2020. Retrieved 26 March 2018.
- Power B (19 March 2015). "Artificial Intelligence Is Almost Ready for Business". Harvard Business Review. Massachusetts General Hospital.
- Bahl M, Barzilay R, Yedidia AB, Locascio NJ, Yu L, Lehman CD (March 2018). "High-Risk Breast Lesions: A Machine Learning Model to Predict Pathologic Upgrade and Reduce Unnecessary Surgical Excision". Radiology. 286 (3): 810–818. doi:10.1148/radiol.2017170549. PMID 29039725.
- Bloch-Budzier S (22 November 2016). "NHS using Google technology to treat patients". BBC News.
- Lorenzetti L (5 April 2016). "Here's How IBM Watson Health is Transforming the Health Care Industry". Fortune.
- Kent J (2018-08-08). "Providers Embrace Predictive Analytics for Clinical, Financial Benefits". HealthITAnalytics. Retrieved 2019-01-16.
- Lee K (4 January 2016). "Predictive analytics in healthcare helps improve OR utilization". SearchHealthIT. Retrieved 2019-01-16.
- Wang, Hong; Zu, Quannan; Chen, Jinglu; Yang, Zhiren; Ahmed, Mohammad Anis (October 2021). "Application of Artificial Intelligence in Acute Coronary Syndrome: A Brief Literature Review". Advances in Therapy. 38 (10): 5078–5086. doi:10.1007/s12325-021-01908-2. ISSN 1865-8652. PMID 34528221. S2CID 237522871.
- Infante, Teresa; Cavaliere, Carlo; Punzo, Bruna; Grimaldi, Vincenzo; Salvatore, Marco; Napoli, Claudio (December 2021). "Radiogenomics and Artificial Intelligence Approaches Applied to Cardiac Computed Tomography Angiography and Cardiac Magnetic Resonance for Precision Medicine in Coronary Heart Disease: A Systematic Review". Circulation: Cardiovascular Imaging. 14 (12): 1133–1146. doi:10.1161/CIRCIMAGING.121.013025. ISSN 1942-0080. PMID 34915726. S2CID 245284764.
- Stewart, Jonathon; Lu, Juan; Goudie, Adrian; Bennamoun, Mohammed; Sprivulis, Peter; Sanfillipo, Frank; Dwivedi, Girish (2021). "Applications of machine learning to undifferentiated chest pain in the emergency department: A systematic review". PLOS ONE. 16 (8): e0252612. Bibcode:2021PLoSO..1652612S. doi:10.1371/journal.pone.0252612. ISSN 1932-6203. PMC 8384172. PMID 34428208.
- Sotirakos, Sara; Fouda, Basem; Mohamed Razif, Noor Adeebah; Cribben, Niall; Mulhall, Cormac; O'Byrne, Aisling; Moran, Bridget; Connolly, Ruairi (February 2022). "Harnessing artificial intelligence in cardiac rehabilitation, a systematic review". Future Cardiology. 18 (2): 154–164. doi:10.2217/fca-2021-0010. ISSN 1744-8298. PMID 33860679. S2CID 233258636.
- Chen, Wei; Sun, Qiang; Chen, Xiaomin; Xie, Gangcai; Wu, Huiqun; Xu, Chen (2021-05-26). "Deep Learning Methods for Heart Sounds Classification: A Systematic Review". Entropy. 23 (6): 667. Bibcode:2021Entrp..23..667C. doi:10.3390/e23060667. ISSN 1099-4300. PMC 8229456. PMID 34073201.
- Zhao, Yuan; Wood, Erica P.; Mirin, Nicholas; Cook, Stephanie H.; Chunara, Rumi (October 2021). "Social Determinants in Machine Learning Cardiovascular Disease Prediction Models: A Systematic Review". American Journal of Preventive Medicine. 61 (4): 596–605. doi:10.1016/j.amepre.2021.04.016. ISSN 1873-2607. PMID 34544559.
- Hibler, Brian P.; Qi, Qiaochu; Rossi, Anthony M. (March 2016). "Current state of imaging in dermatology". Seminars in Cutaneous Medicine and Surgery. 35 (1): 2–8. doi:10.12788/j.sder.2016.001. ISSN 1085-5629. PMID 26963110.
- "Image acquisition in dermatology | DermNet NZ". dermnetnz.org. Retrieved 2021-02-23.
- Chan, Stephanie; Reddy, Vidhatha; Myers, Bridget; Thibodeaux, Quinn; Brownstone, Nicholas; Liao, Wilson (2020-04-06). "Machine Learning in Dermatology: Current Applications, Opportunities, and Limitations". Dermatology and Therapy. 10 (3): 365–386. doi:10.1007/s13555-020-00372-0. ISSN 2193-8210. PMC 7211783. PMID 32253623.
- Han, Seung Seog; Moon, Ik Jun; Lim, Woohyung; Suh, In Suck; Lee, Sam Yong; Na, Jung-Im; Kim, Seong Hwan; Chang, Sung Eun (2020-01-01). "Keratinocytic Skin Cancer Detection on the Face Using Region-Based Convolutional Neural Network". JAMA Dermatology. 156 (1): 29–37. doi:10.1001/jamadermatol.2019.3807. ISSN 2168-6068. PMC 6902187. PMID 31799995.
- Esteva, Andre; Kuprel, Brett; Novoa, Roberto A.; Ko, Justin; Swetter, Susan M.; Blau, Helen M.; Thrun, Sebastian (February 2017). "Dermatologist-level classification of skin cancer with deep neural networks". Nature. 542 (7639): 115–118. Bibcode:2017Natur.542..115E. doi:10.1038/nature21056. ISSN 1476-4687. PMC 8382232. PMID 28117445. S2CID 3767412.
- Noyan, Mehmet Alican; Durdu, Murat; Eskiocak, Ali Haydar (2020-10-27). "TzanckNet: a convolutional neural network to identify cells in the cytology of erosive-vesiculobullous diseases". Scientific Reports. 10 (1): 18314. doi:10.1038/s41598-020-75546-z. ISSN 2045-2322. PMC 7591506. PMID 33110197.
- Patcas R, Bernini DA, Volokitin A, Agustsson E, Rothe R, Timofte R (January 2019). "Applying artificial intelligence to assess the impact of orthognathic treatment on facial attractiveness and estimated age". International Journal of Oral and Maxillofacial Surgery. 48 (1): 77–83. doi:10.1016/j.ijom.2018.07.010. PMID 30087062.
- Patcas R, Timofte R, Volokitin A, Agustsson E, Eliades T, Eichenberger M, Bornstein MM (August 2019). "Facial attractiveness of cleft patients: a direct comparison between artificial-intelligence-based scoring and conventional rater groups". European Journal of Orthodontics. 41 (4): 428–433. doi:10.1093/ejo/cjz007. PMID 30788496. S2CID 73507799.
- "Computer learns to detect skin cancer more accurately than doctors". The Guardian. 29 May 2018.
- Cao, Jia-Sheng; Lu, Zi-Yi; Chen, Ming-Yu; Zhang, Bin; Juengpanich, Sarun; Hu, Jia-Hao; Li, Shi-Jie; Topatana, Win; Zhou, Xue-Yin; Feng, Xu; Shen, Ji-Liang (2021-04-28). "Artificial intelligence in gastroenterology and hepatology: Status and challenges". World Journal of Gastroenterology. 27 (16): 1664–1690. doi:10.3748/wjg.v27.i16.1664. ISSN 1007-9327. PMC 8072192. PMID 33967550.
- Tran, Nam K.; Albahra, Samer; May, Larissa; Waldman, Sarah; Crabtree, Scott; Bainbridge, Scott; Rashidi, Hooman (2021-12-30). "Evolving Applications of Artificial Intelligence and Machine Learning in Infectious Diseases Testing". Clinical Chemistry. 68 (1): 125–133. doi:10.1093/clinchem/hvab239. ISSN 1530-8561. PMID 34969102.
- "COVID-19 Pandemic Impact: Global R&D Spend For AI in Healthcare and Pharmaceuticals Will Increase US$1.5 Billion By 2025". Medical Letter on the CDC & FDA. May 3, 2020 – via Gale Academic OneFile.
- Bhinder, Bhavneet; Gilvary, Coryandar; Madhukar, Neel S.; Elemento, Olivier (April 2021). "Artificial Intelligence in Cancer Research and Precision Medicine". Cancer Discovery. 11 (4): 900–915. doi:10.1158/2159-8290.CD-21-0090. ISSN 2159-8290. PMC 8034385. PMID 33811123.
- Majumder, Anusree; Sen, Debraj (October 2021). "Artificial intelligence in cancer diagnostics and therapy: current perspectives". Indian Journal of Cancer. 58 (4): 481–492. doi:10.4103/ijc.IJC_399_20. ISSN 1998-4774. PMID 34975094. S2CID 240522128.
- Kobie N (1 January 2020). "DeepMind's new AI can spot breast cancer just as well as your doctor". Wired UK. Wired. Retrieved 1 January 2020.
- McKinney SM, Sieniek M, Godbole V, Godwin J, Antropova N, Ashrafian H, et al. (January 2020). "International evaluation of an AI system for breast cancer screening". Nature. 577 (7788): 89–94. Bibcode:2020Natur.577...89M. doi:10.1038/s41586-019-1799-6. PMID 31894144. S2CID 209523468.
- "Artificial intelligence identifies prostate cancer with near-perfect accuracy". EurekAlert!. 27 July 2020. Retrieved 29 July 2020.
- Pantanowitz L, Quiroga-Garza GM, Bien L, Heled R, Laifenfeld D, Linhart C, et al. (1 August 2020). "An artificial intelligence algorithm for prostate cancer diagnosis in whole slide images of core needle biopsies: a blinded clinical validation and deployment study". The Lancet Digital Health. 2 (8): e407–e416. doi:10.1016/S2589-7500(20)30159-X. ISSN 2589-7500. PMID 33328045.
- Försch, Sebastian; Klauschen, Frederick; Hufnagl, Peter; Roth, Wilfried (March 2021). "Artificial Intelligence in Pathology". Deutsches Ärzteblatt International. 118 (12): 199–204. doi:10.3238/arztebl.m2021.0011. ISSN 1866-0452. PMC 8278129. PMID 34024323.
- Steiner, David F.; MacDonald, Robert; Liu, Yun; Truszkowski, Peter; Hipp, Jason D.; Gammage, Christopher; Thng, Florence; Peng, Lily; Stumpe, Martin C. (December 2018). "Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer". The American Journal of Surgical Pathology. 42 (12): 1636–1646. doi:10.1097/PAS.0000000000001151. ISSN 0147-5185. PMC 6257102. PMID 30312179.
- Ho, Jonhan; Ahlers, Stefan M.; Stratman, Curtis; Aridor, Orly; Pantanowitz, Liron; Fine, Jeffrey L.; Kuzmishin, John A.; Montalto, Michael C.; Parwani, Anil V. (2014). "Can digital pathology result in cost savings? A financial projection for digital pathology implementation at a large integrated health care organization". Journal of Pathology Informatics. 5 (1): 33. doi:10.4103/2153-3539.139714. ISSN 2229-5089. PMC 4168664. PMID 25250191.
- Jurmeister, Philipp; Bockmayr, Michael; Seegerer, Philipp; Bockmayr, Teresa; Treue, Denise; Montavon, Grégoire; Vollbrecht, Claudia; Arnold, Alexander; Teichmann, Daniel; Bressem, Keno; Schüller, Ulrich (2019-09-11). "Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases". Science Translational Medicine. 11 (509): eaaw8513. doi:10.1126/scitranslmed.aaw8513. ISSN 1946-6242. PMID 31511427. S2CID 202564269.
- Mistry P (September 2019). "Artificial intelligence in primary care". The British Journal of General Practice. 69 (686): 422–423. doi:10.3399/bjgp19X705137. PMC 6715470. PMID 31467001.
- Blease C, Kaptchuk TJ, Bernstein MH, Mandl KD, Halamka JD, DesRoches CM (March 2019). "Artificial Intelligence and the Future of Primary Care: Exploratory Qualitative Study of UK General Practitioners' Views". Journal of Medical Internet Research. 21 (3): e12802. doi:10.2196/12802. PMC 6446158. PMID 30892270. S2CID 59175658.
- Liyanage H, Liaw ST, Jonnagaddala J, Schreiber R, Kuziemsky C, Terry AL, de Lusignan S (August 2019). "Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges". Yearbook of Medical Informatics. 28 (1): 41–46. doi:10.1055/s-0039-1677901. PMC 6697547. PMID 31022751.
- Kocaballi AB, Ijaz K, Laranjo L, Quiroz JC, Rezazadegan D, Tong HL, et al. (November 2020). "Envisioning an artificial intelligence documentation assistant for future primary care consultations: A co-design study with general practitioners". Journal of the American Medical Informatics Association. 27 (11): 1695–1704. doi:10.1093/jamia/ocaa131. PMC 7671614. PMID 32845984.
- Herter, Willem Ernst; Khuc, Janine; Cinà, Giovanni; Knottnerus, Bart J.; Numans, Mattijs E.; Wiewel, Maryse A.; Bonten, Tobias N.; de Bruin, Daan P.; van Esch, Thamar; Chavannes, Niels H.; Verheij, Robert A. (2022-05-04). "Impact of a Machine Learning-Based Decision Support System for Urinary Tract Infections: Prospective Observational Study in 36 Primary Care Practices". JMIR Medical Informatics. 10 (5): e27795. doi:10.2196/27795. ISSN 2291-9694. PMID 35507396. S2CID 246819392.
- Graham S, Depp C, Lee EE, Nebeker C, Tu X, Kim HC, Jeste DV (November 2019). "Artificial Intelligence for Mental Health and Mental Illnesses: an Overview". Current Psychiatry Reports. 21 (11): 116. doi:10.1007/s11920-019-1094-0. PMC 7274446. PMID 31701320.
- Chekroud, Adam M.; Bondar, Julia; Delgadillo, Jaime; Doherty, Gavin; Wasil, Akash; Fokkema, Marjolein; Cohen, Zachary; Belgrave, Danielle; DeRubeis, Robert; Iniesta, Raquel; Dwyer, Dominic (2021-05-18). "The promise of machine learning in predicting treatment outcomes in psychiatry". World Psychiatry. 20 (2): 154–170. doi:10.1002/wps.20882. ISSN 1723-8617. PMC 8129866. PMID 34002503.
- Fulmer R, Joerin A, Gentile B, Lakerink L, Rauws M (December 2018). "Using Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial". JMIR Mental Health. 5 (4): e64. doi:10.2196/mental.9782. PMC 6315222. PMID 30545815.
- Coppersmith G, Leary R, Crutchley P, Fine A (January 2018). "Natural Language Processing of Social Media as Screening for Suicide Risk". Biomedical Informatics Insights. 10: 1178222618792860. doi:10.1177/1178222618792860. PMC 6111391. PMID 30158822.
- Brunn M, Diefenbacher A, Courtet P, Genieys W (August 2020). "The Future is Knocking: How Artificial Intelligence Will Fundamentally Change Psychiatry". Academic Psychiatry. 44 (4): 461–466. doi:10.1007/s40596-020-01243-8. PMID 32424706. S2CID 218682746.
- Rutledge, Robb B; Chekroud, Adam M; Huys, Quentin JM (2019-04-01). "Machine learning and big data in psychiatry: toward clinical applications". Current Opinion in Neurobiology. Machine Learning, Big Data, and Neuroscience. 55: 152–159. doi:10.1016/j.conb.2019.02.006. ISSN 0959-4388. PMID 30999271. S2CID 115202826.
- Pisarchik AN, Maksimenko VA, Hramov AE (October 2019). "From Novel Technology to Novel Applications: Comment on "An Integrated Brain-Machine Interface Platform With Thousands of Channels" by Elon Musk and Neuralink". Journal of Medical Internet Research. 21 (10): e16356. doi:10.2196/16356. PMC 6914250. PMID 31674923. S2CID 207818415.
- Hosny A, Parmar C, Quackenbush J, Schwartz LH, Aerts HJ (August 2018). "Artificial intelligence in radiology". Nature Reviews. Cancer. 18 (8): 500–510. doi:10.1038/s41568-018-0016-5. PMC 6268174. PMID 29777175.
- Liu, Xiaoxuan; Faes, Livia; Kale, Aditya U; Wagner, Siegfried K; Fu, Dun Jack; Bruynseels, Alice; Mahendiran, Thushika; Moraes, Gabriella; Shamdas, Mohith; Kern, Christoph; Ledsam, Joseph R (2019-10-01). "A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis". The Lancet Digital Health. 1 (6): e271–e297. doi:10.1016/S2589-7500(19)30123-2. ISSN 2589-7500. PMID 33323251. S2CID 204037561.
- Richardson, Michael L.; Garwood, Elisabeth R.; Lee, Yueh; Li, Matthew D.; Lo, Hao S.; Nagaraju, Arun; Nguyen, Xuan V.; Probyn, Linda; Rajiah, Prabhakar; Sin, Jessica; Wasnik, Ashish P. (September 2021). "Noninterpretive Uses of Artificial Intelligence in Radiology". Academic Radiology. 28 (9): 1225–1235. doi:10.1016/j.acra.2020.01.012. ISSN 1878-4046. PMID 32059956.
- Seifert, Robert; Weber, Manuel; Kocakavuk, Emre; Rischpler, Christoph; Kersting, David (March 2021). "Artificial Intelligence and Machine Learning in Nuclear Medicine: Future Perspectives". Seminars in Nuclear Medicine. 51 (2): 170–177. doi:10.1053/j.semnuclmed.2020.08.003. ISSN 1558-4623. PMID 33509373. S2CID 224863373.
- Liang H, Tsui BY, Ni H, Valentim CC, Baxter SL, Liu G, et al. (March 2019). "Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence". Nature Medicine. 25 (3): 433–438. doi:10.1038/s41591-018-0335-9. PMID 30742121. S2CID 59945159.
- Hamet P, Tremblay J (April 2017). "Artificial intelligence in medicine". Metabolism. Insights Into the Future of Medicine: Technologies, Concepts, and Integration. 69S: S36–S40. doi:10.1016/j.metabol.2017.01.011. PMID 28126242.
- Pivovarov R, Elhadad N (September 2015). "Automated methods for the summarization of electronic health records". Journal of the American Medical Informatics Association. 22 (5): 938–47. doi:10.1093/jamia/ocv032. PMC 4986665. PMID 25882031. S2CID 1452.
- Yang M (2020-08-19). "Painful conversations: Therapeutic chatbots and public capacities". Communication and the Public. 5 (1–2): 35–44. doi:10.1177/2057047320950636. PMC 7441483.
- Pouke M, Häkkilä J (December 2013). "Elderly healthcare monitoring using an avatar-based 3D virtual environment". International Journal of Environmental Research and Public Health. 10 (12): 7283–98. doi:10.3390/ijerph10127283. PMC 3881167. PMID 24351747. S2CID 18535954.
- Ferrante FE (June 2005). "Evolving telemedicine/ehealth technology". Telemedicine Journal and e-Health. 11 (3): 370–83. doi:10.1089/tmj.2005.11.370. PMID 16035932.
- Garza-Galicia, M., Sosa, M., Low, R., & Simini, F. (2017). Enseñanza de un Programa de Ortesis Mental Clínica: Experiencia con Estudiantes de Medicina en Uruguay. Memorias Del Congreso Nacional De Ingeniería Biomédica, 4(1), 91–94. Retrieved from: http://memorias.somib.org.mx/index.php/memorias/article/view/221
- Medrano IH, Guijarro JT, Belda C, Ureña A, Salcedo I, Anke LE, Saggion H (2018). "Savana: Re-using Electronic Health Records with Artificial Intelligence". International Journal of Interactive Multimedia and Artificial Intelligence. 4 (7): 8–12. doi:10.9781/ijimai.2017.03.001. ISSN 1989-1660.
- Eren A, Subasi A, Coskun O (February 2008). "A decision support system for telemedicine through the mobile telecommunications platform". Journal of Medical Systems. 32 (1): 31–5. doi:10.1007/s10916-007-9104-x. PMID 18333403. S2CID 11082133.
- Bennett CC, Doub TW, Selove R (April 2012). "EHRs connect research and practice: Where predictive modeling, artificial intelligence, and clinical decision support intersect". Health Policy and Technology. 1 (2): 105–114. arXiv:1204.4927. doi:10.1016/j.hlpt.2012.03.001. ISSN 2211-8837. S2CID 25022446.
- Bokharaeian B, Diaz A, Chitsaz H (2016). "Enhancing Extraction of Drug-Drug Interaction from Literature Using Neutral Candidates, Negation, and Clause Dependency". PLOS ONE. 11 (10): e0163480. Bibcode:2016PLoSO..1163480B. doi:10.1371/journal.pone.0163480. PMC 5047471. PMID 27695078.
- Cai R, Liu M, Hu Y, Melton BL, Matheny ME, Xu H, et al. (February 2017). "Identification of adverse drug-drug interactions through causal association rule discovery from spontaneous adverse event reports". Artificial Intelligence in Medicine. 76: 7–15. doi:10.1016/j.artmed.2017.01.004. PMC 6438384. PMID 28363289.
- Christopoulou F, Tran TT, Sahu SK, Miwa M, Ananiadou S (January 2020). "Adverse drug events and medication relation extraction in electronic health records with ensemble deep learning methods". Journal of the American Medical Informatics Association. 27 (1): 39–46. doi:10.1093/jamia/ocz101. PMC 6913215. PMID 31390003.
- Zhou D, Miao L, He Y (May 2018). "Position-aware deep multi-task learning for drug-drug interaction extraction" (PDF). Artificial Intelligence in Medicine. 87: 1–8. doi:10.1016/j.artmed.2018.03.001. PMID 29559249. S2CID 3951020.
- García JS (2013-04-14). Optimización del tratamiento de enfermos pluripatológicos en atención primaria UCAMI HHUU Virgen del Rocio (Report). Sevilla. Spain – via ponencias de la II Reunión de Paciente Pluripatológico y Edad Avanzada Archived.
- Herrero-Zazo M, Segura-Bedmar I, Martínez P, Declerck T (October 2013). "The DDI corpus: an annotated corpus with pharmacological substances and drug-drug interactions". Journal of Biomedical Informatics. 46 (5): 914–20. doi:10.1016/j.jbi.2013.07.011. PMID 23906817.
- Segura Bedmar I, Martínez P, Herrero Zazo M (June 2013). Semeval-2013 task 9: Extraction of drug-drug interactions from biomedical texts (ddiextraction 2013). Second Joint Conference on Lexical and Computational Semantics. Vol. 2. Association for Computational Linguistics. pp. 341–350.
- Xu B, Shi X, Yin Y, Zhao Z, Zheng W, Lin H, et al. (July 2019). "Incorporating User Generated Content for Drug Drug Interaction Extraction Based on Full Attention Mechanism". IEEE Transactions on NanoBioscience. 18 (3): 360–367. doi:10.1109/TNB.2019.2919188. PMID 31144641. S2CID 169038906.
- Wakefield J (30 January 2020). "Artificial intelligence-created medicine to be used on humans for first time". BBC News.
- "Novel molecules designed by artificial intelligence in 21 days are validated in mice". EurekAlert!. 2 September 2019. Retrieved 5 September 2019.
- "Has AI Discovered a Drug Now? Guess". Science. 4 September 2019. Retrieved 5 September 2019.
- Zhavoronkov A, Ivanenkov YA, Aliper A, Veselov MS, Aladinskiy VA, Aladinskaya AV, et al. (September 2019). "Deep learning enables rapid identification of potent DDR1 kinase inhibitors". Nature Biotechnology. 37 (9): 1038–1040. doi:10.1038/s41587-019-0224-x. PMID 31477924. S2CID 201716327.
- "Deep Genomics Nominates Industry's First AI-Discovered Therapeutic Candidate". Deep Genomics. 25 September 2019. Archived from the original on 25 September 2019. Retrieved 25 September 2019.
- Quan XI, Sanderson J (December 2018). "Understanding the Artificial Intelligence Business Ecosystem". IEEE Engineering Management Review. 46 (4): 22–25. doi:10.1109/EMR.2018.2882430. ISSN 0360-8581. S2CID 59525052.
- Abou-Zahra S, Brewer J, Cooper M (2018-04-23). "Artificial Intelligence (AI) for Web Accessibility: Is Conformance Evaluation a Way Forward?". Proceedings of the Internet of Accessible Things. W4A '18. Lyon, France: Association for Computing Machinery: 1–4. doi:10.1145/3192714.3192834. ISBN 978-1-4503-5651-0. S2CID 49863409.
- Guo J, Li B (2018-08-01). "The Application of Medical Artificial Intelligence Technology in Rural Areas of Developing Countries". Health Equity. 2 (1): 174–181. doi:10.1089/heq.2018.0037. PMC 6110188. PMID 30283865.
- Lacassie E, Marquet P, Martin-Dupont S, Gaulier JM, Lachâtre G (September 2000). "A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass spectrometry". Journal of Forensic Sciences. 45 (5): 1154–8. doi:10.1520/JFS14845J. PMID 11005196.
- Arlene R. Fulkerson (17 May 2014). "Artificial Intelligence in Healthcare: Machine Learning Use Cases". AI Healthcare.
- Davenport T, Kalakota R (June 2019). "The potential for artificial intelligence in healthcare". Future Healthcare Journal. 6 (2): 94–98. doi:10.7861/futurehosp.6-2-94. PMC 6616181. PMID 31363513.
- U.S News Staff (2018-09-20). "Artificial Intelligence Continues to Change Health Care". US News.
- "AI for Health CareArtificial Intelligence for Health Care". GrayRipples.com | AI | iOS | Android | PowerApps. 2020-03-04. Retrieved 2020-11-04.
- Baric-Parker J, Anderson EE (November 2020). "Patient Data-Sharing for AI: Ethical Challenges, Catholic Solutions". The Linacre Quarterly. 87 (4): 471–481. doi:10.1177/0024363920922690. PMC 7551527. PMID 33100395.
- Nordling L (September 2019). "A fairer way forward for AI in health care". Nature. 573 (7775): S103–S105. Bibcode:2019Natur.573S.103N. doi:10.1038/d41586-019-02872-2. PMID 31554993. S2CID 202749329.
- Reddy S, Allan S, Coghlan S, Cooper P (March 2020). "A governance model for the application of AI in health care". Journal of the American Medical Informatics Association. 27 (3): 491–497. doi:10.1093/jamia/ocz192. PMC 7647243. PMID 31682262.
- Pumplun L, Fecho M, Wahl N, Peters F, Buxmann P (2021). "Adoption of Machine Learning Systems for Medical Diagnostics in Clinics: Qualitative Interview Study". Journal of Medical Internet Research. 23 (10): e29301. doi:10.2196/29301. PMC 8556641. PMID 34652275. S2CID 238990562.
- Bennett CC, Doub TW, Selove R (June 2012). "EHRs connect research and practice: Where predictive modeling, artificial intelligence, and clinical decision support intersect". Health Policy and Technology. 1 (2): 105–14. arXiv:1204.4927. doi:10.1016/j.hlpt.2012.03.001. S2CID 25022446.
- Wahl B, Cossy-Gantner A, Germann S, Schwalbe NR (2018). "Artificial intelligence (AI) and global health: how can AI contribute to health in resource-poor settings?". BMJ Global Health. 3 (4): e000798. doi:10.1136/bmjgh-2018-000798. PMC 6135465. PMID 30233828.
- de Jesus A (21 November 2019). "Artificial Intelligence in Epidemiology". Emerj. AI Research and Advisory Company.
- "Accelerating America's Leadership in Artificial Intelligence". whitehouse.gov. 11 February 2019 – via National Archives.