Asialoglycoprotein receptor

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asialoglycoprotein receptor 1
Symbol ASGR1
Entrez 432
HUGO 742
OMIM 108360
RefSeq NM_001671
UniProt P07306
Other data
Locus Chr. 17 p13-p11
asialoglycoprotein receptor 2
Symbol ASGR2
Entrez 433
HUGO 743
OMIM 108361
RefSeq NM_080914
UniProt P07307
Other data
Locus Chr. 17 p

The asialoglycoprotein receptors are lectins which bind asialoglycoprotein, glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human carcinoma cell lines. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.

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