Ghebremichael made her Broadway debut in 1999, playing Rusty, Wendy Jo, Urleen, and the Ensemble (varying) in Footloose. She later appeared in the ensembles of Wicked and Spamalot (she also played the minstrel) on Broadway, as well as Lone Star Love and In the Heights (for which she won a Drama Desk Award) off-Broadway. In 2007, she played Pilar in Legally Blonde on Broadway. The show was filmed for TV, and in 2008 she began also understudying the roles of Shandi and Brooke Wyndham. She also appeared on the reality competition show Legally Blonde: The Musical – The Search for Elle Woods twice. The show closed in 2008, and after appearing in the film Confessions of a Shopaholic, Ghebremichael began playing Raina Pearl in the web series Submissions Only. She also played Shawanda in the original Broadway cast of Elf: The Musical, and in 2011 she appeared in the ensemble of The Book of Mormon on Broadway. She later played Nabulungi in the show, and is currently playing the role in the West End production, which she started in February 2016. In 2015, she appeared as a munchkin in The Wiz Live! on NBC. In 2017 she joined the West End cast of Dreamgirls as Lorrell Robinson.