Further information: Testicular infertility factors
|(A)spermia - complete lack of semen|
|(Asthenozoo)spermia - reduced sperm motility|
|(Azoo)spermia - absence of sperm cells in semen|
|(Hyper)spermia - large semen volume|
|(Hypo)spermia - small semen volume|
|(Oligozoo)spermia - few spermatozoa in semen|
|(Necrozoo)spermia - dead or immobile sperms|
|(Teratozoo)spermia - sperm with abnormal morphology|
Asthenozoospermia (or asthenospermia) is the medical term for reduced sperm motility. Complete asthenozoospermia, that is, 100% immotile spermatozoa in the ejaculate, is reported at a frequency of 1 of 5000 men. Causes of complete asthenozoospermia include metabolic deficiencies, ultrastructural abnormalities of the sperm flagellum (see Primary ciliary dyskinesia) and necrozoospermia.
It decreases the sperm quality and is therefore one of the major causes of infertility or reduced fertility in men. A method to increase the chance of pregnancy is ICSI. The percentage of viable spermatozoa in complete asthenozoospermia varies between 0 and 100%.
Sperm DNA fragmentation level is higher in men with sperm motility defects (asthenozoospermia) than in men with oligozoospermia or teratozoospermia. Among men with asthenozoospermia, 31% were found to have high levels of DNA fragmentation. As reviewed by Wright et al., high levels of DNA fragmentation have been shown to be a robust indicator of male infertility.
Asthenozoospermia and DHA
In 2015, Eslamian et al found a correlation between the composition of the sperm lipid membrane and the odds of having asthenozoospermia. The sperm that have more polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) shown better fertility rusults. DHA (docosahexaenoic acid) is an acid form by six double bons which allows the fluidy of the membrane, necessary to the fusion with the ovule.
Studies in mice have shown that DHA is essential for acrosome reaction and a DHA deficiency results in abnormal sperm morphology, lost of motility and infertility; which can be restored by dietary DHA supplementation.
Furthermore, the supplementation with DHA in human has been reported to increase sperm motility. But also, DHA supplement can protect spermatozoa against the damage caused by the cryopresevation process.
- Ortega, C.; Verheyen, G.; Raick, D.; Camus, M.; Devroey, P.; Tournaye, H. (2011). "Absolute asthenozoospermia and ICSI: What are the options?". Human Reproduction Update. 17 (5): 684–692. doi:10.1093/humupd/dmr018. PMID 21816768.
- Belloc S, Benkhalifa M, Cohen-Bacrie M, Dalleac A, Chahine H, Amar E, Zini A (2014). "Which isolated sperm abnormality is most related to sperm DNA damage in men presenting for infertility evaluation". J. Assist. Reprod. Genet. 31 (5): 527–32. doi:10.1007/s10815-014-0194-3. PMC 4016368. PMID 24566945.
- Wright C, Milne S, Leeson H (2014). "Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility". Reprod. Biomed. Online. 28 (6): 684–703. doi:10.1016/j.rbmo.2014.02.004. PMID 24745838.
González-Ravina, Cristina; Aguirre-Lipperheide, Mercedes; Pinto, Francisco; Martín-Lozano, David; Fernández-Sánchez, Manuel; Blasco, Víctor; Santamaría-López, Esther; Candenas, Luz (2018). "Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function". Reproductive Biology. 18 (3): 282–288. doi:10.1016/j.repbio.2018.06.002.
- González-Ravina, Cristina; Aguirre-Lipperheide, Mercedes; Pinto, Francisco; Martín-Lozano, David; Fernández-Sánchez, Manuel; Blasco, Víctor; Santamaría-López, Esther; Candenas, Luz (2018). "Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function". Reproductive Biology. 18 (3): 282–288. doi:10.1016/j.repbio.2018.06.002. PMID 29934046.
|This article related to the genitourinary system is a stub. You can help Wikipedia by expanding it.|