It is located on the River Ivel, just to the north of Stotfold. Hinxworth, in the neighbouring county of Hertfordshire, is also nearby. The Great North Road passes just to the east of the village. The A1 was improved around 1958, began in 1957, known as the Edworth to Astwick Turn scheme. It is the first non-motorway section of dual-carriageway north of the Baldock motorway bypass.
The village has one church, the Parish Church of St Guthlac, one of only two churches in England dedicated to this saint. Another notable building is the moated Astwick Bury, which dates from around 1700 and is Grade II listed.
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