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Asuragen is a global diagnostic products company delivering solutions that build knowledge and understanding of complex clinical questions. Asuragen’s application of its deep scientific heritage and molecular expertise delivers diagnostic products in oncology and genetics that provide the best answers with optimal workflows – so time can be spent delivering actionable insights, rather than searching for them. With innovative approaches to kit development and a broad range of molecular chemistries, Asuragen produces assays that ensure reproducible results. From discovery and development to regulatory support to global commercialization, they also provide a tailored approach that efficiently delivers custom and companion diagnostic products for their partners.

Asuragen
IndustryBiotechnology
FoundedMarch 2006 (2006-03)
Headquarters
Austin, Texas
,
United States
DivisionsDiagnostics, Translational Diagnostics
Websitehttp://www.asuragen.com/

Diagnostics

Offerings includes molecular diagnostic products providing identification of genetic abnormalities associated with oncology and genetic diseases. Multiplex assay oncology tests for leukemia, including abnormalities associated with CML, BCR/ABL ALL, APL, AML, NPM1, RNA stabilization products with its Armored RNA technology and a genetic test (AmplideX[1]) and software[2] for Fragile X Mental Retardation FMR1.[3]

Services

RNA-related services, including analyst isolation/preparation from multiple sample types, genomic profiling, miRNA/mRNA expression profiling, biomarker discovery, assay design and validation, CLIA-based clinical testing, bioinformatic analysis, and regulatory and project management services.[4]

Clinical Reference Laboratory

The laboratory is Clinical Laboratory Improvement Amendment (CLIA) certified and College of American Pathology (CAP) accredited. Clinical laboratory testing services include Xpansion Interpreter® which utilizes novel PCR technology to comprehensively genotype the 5' region of the FMR1 gene in order to assess the risk of expansion in future generations.[5]

Asuragen Patents

Methods and Compositions Involving MicroRNA: The following present inventions concern methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.Patent No. 7888010 issued 02/15/2011, Patent No. 8003320 issued 08/23/2011, Patent No. 7919245 issued 04/05/2011, Patent No. 8058250 issued 11/15/2011, Patent No. 7993831 issued 08/09/2011

Ribonuclease Resistant Viral RNA Standards: The following present inventions are directed to the process of creating a recombinant nucleic acid standard which is resistant to ribonuclease digestion and is non-infectious. These "ARMORED RNA" standards are ideal as RNA standards for the quantification of RNA viruses such as HIV and HCV from human body fluids such as blood and cerebrospinal fluid. Patent No. 5677124 issued 010/14/1997, Patent No. 5919625 issued 07/06/1999

Ribonuclease Resistant RNA Preparation and Utilization: The following present inventions relate to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed. Patent No. 5939262 issued 08/17/1999, Patent No. 6214982 issued 04/10/2001, Patent No. 6399307 issued 06/04/2001, Patent No. 7033749 issued 04/25/2006 [6]

History

In 1989 CEO/CSO and founder Dr. Matt Winkler left his position as an Associate Professor of Zoology at the University of Texas and formed a molecular biology reagent company called Ambion. Winkler then formed Asuragen from Ambion's Molecular Diagnostics and Pharmacogenomic Service Divisions following the March 2006 sale of the Research Products Division of Ambion Inc. to the Applied Biosystems Group (currently Life Technologies).[7] In December 2007, the microRNA therapeutics activities were moved into a new entity called Mirna Therapeutics.[8]

References

  1. ^ "AmplideX FMR1- Asuragen". Asuragen. Retrieved 2016-01-05.
  2. ^ Automated Software Solution for Accurate Sizing of the FMR1 CGG Repeat Region, November 5, 2013
  3. ^ Seldon, Johathan (May 28, 2006), "49M in venture funds bring Asuragen to life", Austin Business Journal, pp. D2, D4
  4. ^ Seldon, Johathan (May 28, 2006), "49M in venture funds bring Asuragen to life", Austin Business Journal, pp. D2, D4
  5. ^ Filipovic-Sadic. "A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome".
  6. ^ Asuragen Inc. Granted Patents[permanent dead link‍]
  7. ^ Rockwell, Lily (December 10, 2007), "Asuragen gets push forward", Austin American Statesman, pp. D2, D4
  8. ^ Harrington, Kate (January 18–24, 2008), "Asuragen launches new microRNA firm", Austin Business Journal, pp. 3, 7
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