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Combination of
AtazanavirHIV protease inhibitor
CobicistatCytochrome P450 (CYP3A) inhibitor
Clinical data
Trade namesEvotaz
AHFS/Drugs.comProfessional Drug Facts
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ATC code
Legal status
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Atazanavir/cobicistat, sold under the brand name Evotaz, is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS.[2][3] It contains atazanavir and cobicistat.[2][3][4] Atazanavir is an HIV protease inhibitor and cobicistat is an inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family.[2]

Atazanavir/cobicistat was approved by the Food and Drug Administration (FDA) for medical use in United States in January 2015.[5][6] It was approved for medical use in the European Union in July 2015.[3]

Medical uses[edit]

Atazanavir/cobicistat is indicated for use in combination with other antiretroviral agents for the treatment of HIV‑1 infection in people weighing at least 35 kilograms (77 lb).[2][3]


  1. ^ "Evotaz 300 mg/150 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Retrieved 9 July 2021.
  2. ^ a b c d e "Evotaz- atazanavir and cobicistat tablet". DailyMed. Retrieved 25 May 2021.
  3. ^ a b c d e "Evotaz EPAR". European Medicines Agency (EMA). Retrieved 25 May 2021.
  4. ^ Crutchley RD, Guduru RC, Cheng AM (2016). "Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection". HIV/AIDS: Research and Palliative Care. 8: 47–65. doi:10.2147/HIV.S99063. PMC 4790521. PMID 27022304.
  5. ^ "U.S. Food and Drug Administration Approves Bristol-Myers Squibb's Evotaz (atazanavir and cobicistat) for the Treatment of HIV-1 Infection in Adults" (Press release). Bristol-Myers Squibb. Archived from the original on 2020-08-08. Retrieved 2018-06-28.
  6. ^ "Evotaz (atazanavir and cobicistat) Tablet". U.S. Food and Drug Administration (FDA). 15 April 2016. Retrieved 25 May 2021. "Summary Report" (PDF).

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