|Chemical and physical data|
|Molar mass||612.59 g·mol−1 144|
In September 2018, it was announced that Tecentriq prolongs survival in extensive stage small cell lung cancer treatment, according to study results presented at the 19th World Conference on Lung Cancer (WCLC) in Toronto, Canada.
In May 2018, Tecentriq was in combination with Avastin and standard chemotherapy for some patients with lung cancer was granted priority review.
In March 2019, it was approved by the FDA for advanced triple-negative breast cancer treatment.
In May 2016 FDA granted accelerated approval to atezolizumab for locally advanced or metastatic urothelial carcinoma treatment after failure of cisplatin-based chemotherapy. The confirmatory trial (to convert the accelerated approval into a full approval) failed to achieve its primary endpoint of overall survival.
In October 2016, FDA approved atezolizumab for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose disease progressed during or following platinum-containing chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving atezolizumab.
Mechanism of action
Atezolizumab blocks the interaction of PD-L1 with programmed cell death protein 1 (PD-1) and CD80 receptors (B7-1Rs). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by atezolizumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as "immune checkpoint inhibition."
For some cancers (notably bladder) the probability of benefit is related to PD-L1 expression, but most cancers with PD-L1 expression still do not respond, and many (about 15%) without PD-L1 expression do respond.
- "Genentech Presents Positive Results of Atezolizumab in Advanced Bladder Cancer". Oct 2, 2015.
- Shields, Michael (11 Apr 2016). "Roche says FDA fast tracks atezolizumab in specific type of lung cancer". Reuters. Retrieved 11 Apr 2016.
- "FDA approves new, targeted treatment for bladder cancer". FDA. 18 May 2016. Retrieved 20 May 2016.
- "Roche's shocking Tecentriq fail raises red flag for bladder cancer rivals | FiercePharma". www.fiercepharma.com. Retrieved 2017-05-11.
- "FDA approves new treatment for non-small cell lung cancer". FDA. 18 Oct 2016. Retrieved 18 May 2016.
- McKee, Selina (2018-05-08). "First-line use of Roche's Tecentriq given priority review". www.pharmatimes.com. Retrieved 2018-05-08.
- Schmid, Peter; Adams, Sylvia; Rugo, Hope S.; Schneeweiss, Andreas; Barrios, Carlos H.; Iwata, Hiroji; Diéras, Véronique; Hegg, Roberto; Im, Seock-Ah (2018-10-20). "Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer". New England Journal of Medicine. 379 (22): 2108–2121. doi:10.1056/nejmoa1809615. ISSN 0028-4793. PMID 30345906.
- "Roche scores first U.S. approval of immunotherapy for breast cancer | STAT". www.statnews.com. Retrieved 2019-03-09.
- Failed confirmatory trial raises questions about atezolizumab for advanced urothelial cancer. June 2017
- Concurrent Tecentriq Adds First Survival Benefit Seen in Small Cell Lung Cancer in 20 Years | https://www.curetoday.com/articles/concurrent-tecentriq-adds-first-survival-benefit-seen-in-small-cell-lung-cancer-in-20-years
- FDA Professional Drug Information for Tecentriq.
- Syn, Nicholas L; Teng, Michele W L; Mok, Tony S K; Soo, Ross A (2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet Oncology. 18 (12): e731–e741. doi:10.1016/s1470-2045(17)30607-1.
- "Search of: MPDL3280A - List Results - ClinicalTrials.gov".
- Bendell, Johanna C.; Kim, Tae Won; Goh, Boon C.; Wallin, Jeffrey; Oh, Do-Youn; Han, Sae-Won; Lee, Carrie B.; Hellmann, Matthew David; Desai, Jayesh; Lewin, Jeremy Howard; Solomon, Benjamin J.; Chow, Laura Quan Man; Miller, Wilson H.; Gainor, Justin F.; Flaherty, Keith; Infante, Jeffrey R.; Das-Thakur, Meghna; Foster, Paul; Cha, Edward; Bang, Yung-Jue. "Clinical activity and safety of cobimetinib (cobi) and atezolizumab in colorectal cancer (CRC). - 2016 ASCO Annual Meeting Abstracts". Meeting Abstracts.
- "MPDL3280A Shows Activity in Triple-Negative Breast Cancer".