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Combination of
AtovaquoneAntimalarial medication
ProguanilAntimalarial medication
Clinical data
Trade namesMalarone, Malanil, others
License data
  • AU: B2
Routes of
By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)[1]
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
CAS Number
PubChem CID
CompTox Dashboard (EPA)
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Atovaquone/proguanil, sold under the brand name Malarone among others, is a fixed-dose combination medication used to treat and prevent malaria, including chloroquine-resistant malaria.[2][3] It contains atovaquone and proguanil.[3] It is not recommended for severe or complicated malaria.[3] It is taken by mouth.[3]

Common side effects include abdominal pain, vomiting, diarrhea, cough, and itchiness.[3] Serious side effects may include anaphylaxis, Stevens–Johnson syndrome, hallucinations, and liver problems.[3][4] Side effects are generally mild.[5] It is unclear if use during pregnancy or breastfeeding is safe for the baby.[6] It is not recommended to prevent malaria in those with poor kidney function.[4] Atovaquone works by interfering with the function of mitochondria in malaria while proguanil blocks dihydrofolate reductase.[3]

Atovaquone/proguanil was approved for medical use in the United States in 2000.[3] It has been available as a generic medication since 2011.[7]

Medical uses[edit]

Malarone tablets, as issued in the UK.

Malaria treatment[edit]

Atovaquone/proguanil is not normally used to treat severe malaria, when an injectable drug such as quinine is used instead.[citation needed]

Malaria prevention[edit]

Since some malaria strains are resistant to atovaquone/proguanil, it is not effective in all parts of the world. It must be taken with a fatty meal, or at least some milk, for the body to absorb it adequately—and to avoid painful stomach irritation, which proguanil frequently causes if taken without food. Also, stomach irritation may occur if one lies down within a half hour after taking this medicine.[citation needed]


Proguanil acts as a mitochondrial sensitiser and synergizes with atovaquone. When atovaquone is used as a sole agent, a high natural frequency of cytochrome b mutants leads to a high failure rate. This is potentially due to the high lipophilicity and slow uptake of atovaquone, which results in a relatively prolonged period of parasite exposure at ineffective concentrations.[8] Specific mutations (Y268S, Y268C) have been shown to confer resistance in vivo,[9][10][11] but the other mechanisms of resistance remain unknown.[12]

Adverse effects[edit]

Side effects are generally mild.[5] While some people experience side effects, such as coughing, diarrhea, dizziness, headache, loss of appetite, mouth sores, nausea, stomach pain, vomiting, or weakness, the majority have none or few of these.[5]

Mechanism of action[edit]

Atovaquone selectively inhibits the malarial cytochrome bc1 complex in the parasitic electron transport chain, collapsing the mitochondrial membrane potential.[13] The malarial electron transport chain does not contribute significantly to ATP synthesis; thus, it is believed that parasite death is due to the indirect inhibition of dihydroorotate dehydrogenase, which requires transport chain function and is essential to pyrimidine biosynthesis.[14]

Proguanil, via its metabolite cycloguanil, functions as a dihydrofolate reductase inhibitor, halting parasitic deoxythymidylate synthesis.[15]


A standard tablet of Malarone contains 100 mg of proguanil hydrochloride and 250 mg of atovaquone. A pediatric tablet contains 25 mg of proguanil hydrochloride and 62.5 mg of atovaquone.[citation needed]


Glaxo Wellcome patented the combination of atovaquone and proguanil to treat malaria in 1999. Patent protection expired in 2013.[16] The U.S. Food and Drug Administration (FDA) approved a generic formulation from Glenmark Generics in 2011.[17] In February 2013, the United Kingdom High Court revoked Glaxo's patent on grounds of obviousness, which clears the way for firms to sell generic versions there.[18]


  1. ^ "Atovaquopro Lupin (Generic Health Pty Ltd)". Therapeutic Goods Administration (TGA). 28 September 2022. Archived from the original on 12 October 2022. Retrieved 29 April 2023.
  2. ^ Nakato, Halima; Vivancos, Roberto; Hunter, Paul R. (1 November 2007). "A systematic review and meta-analysis of the effectiveness and safety of atovaquone–proguanil (Malarone) for chemoprophylaxis against malaria". Journal of Antimicrobial Chemotherapy. 60 (5): 929–936. doi:10.1093/jac/dkm337. ISSN 0305-7453. PMID 17848375.
  3. ^ a b c d e f g h "Atovaquone and Proguanil Hydrochloride Monograph for Professionals". American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 12 September 2019.
  4. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 604. ISBN 9780857113382.
  5. ^ a b c "Malarone Side Effects: Common, Severe, Long Term". Archived from the original on 16 August 2019. Retrieved 12 September 2019.
  6. ^ "Atovaquone / proguanil Use During Pregnancy". Archived from the original on 16 August 2019. Retrieved 12 September 2019.
  7. ^ "Generic Malarone Availability". Archived from the original on 16 August 2019. Retrieved 12 September 2019.
  8. ^ Srivastava, Indresh K.; Vaidya, Akhil B. (1 June 1999). "A Mechanism for the Synergistic Antimalarial Action of Atovaquone and Proguanil". Antimicrobial Agents and Chemotherapy. 43 (6): 1334–1339. doi:10.1128/AAC.43.6.1334. ISSN 0066-4804. PMC 89274. PMID 10348748.
  9. ^ Färnet A, Lindberg J, Gil P, et al. (2003). "Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguoanil hydrochloride: case reports". Br Med J. 326 (7390): 628–29. doi:10.1136/bmj.326.7390.628. PMC 151974. PMID 12649236.
  10. ^ Fivelman QL, Butcher GA, Adagu IS, et al. (2002). "Malarone treatment failure and in-vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria". Malaria Journal. 1: 1. doi:10.1186/1475-2875-1-1. PMC 111499. PMID 12057021.
  11. ^ Schwartz E, Bujanover S, Kain KC (2003). "Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveller to east Africa". Clin Infect Dis. 37 (3): 450–51. doi:10.1086/375599. PMID 12884171.
  12. ^ Wichmann O, Muehlen M, Gruss H, et al. (2004). "Malarone treatment failure not associated with previously described mutations in the cytochrome b gene". Malaria Journal. 3: 14. doi:10.1186/1475-2875-3-14. PMC 425592. PMID 15186499.
  13. ^ Fry, Mitchell; Pudney, Mary (1 April 1992). "Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)". Biochemical Pharmacology. 43 (7): 1545–1553. doi:10.1016/0006-2952(92)90213-3. PMID 1314606.
  14. ^ Srivastava, Indresh K.; Rottenberg, Hagai; Vaidya, Akhil B. (14 February 1997). "Atovaquone, a Broad Spectrum Antiparasitic Drug, Collapses Mitochondrial Membrane Potential in a Malarial Parasite". Journal of Biological Chemistry. 272 (7): 3961–3966. doi:10.1074/jbc.272.7.3961. ISSN 0021-9258. PMID 9020100.
  15. ^ "Our prescription medicines | GSK US" (PDF). Archived from the original (PDF) on 4 September 2011. Retrieved 28 September 2011.
  16. ^ "Generic Malarone Availability". Archived from the original on 16 August 2019. Retrieved 23 January 2018.
  17. ^ "Drug Details". Archived from the original on 27 August 2021. Retrieved 1 May 2013.
  18. ^ "Atovaquone Proguanil (Malarone) Patent Revoked & Glenmark Launches First UK Generic". Archived from the original on 16 April 2013. Retrieved 1 May 2013.