Autoimmune progesterone dermatitis may appear as urticarialpapules, deep gyrate lesions, papulovesicular lesions, an eczematous eruption, or as targetoid lesions.:82 Autoimmune progesterone dermatitis initially manifests with eye symptoms, e.g. burning, and progresses into rashes. Its relapsing-remitting pattern in women correspond to the progesterone levels during the menstrual cycle, which spike twice a month. It is an extremely rare disease, only perhaps 50 cases have ever been reported.