Auxilin

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DNAJC6
Protein DNAJC6 PDB 1n4c.png
Identifiers
Aliases DNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6
External IDs MGI: 1919935 HomoloGene: 8865 GeneCards: DNAJC6
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256864
NM_001256865
NM_014787

NM_001164583
NM_001164584
NM_001164585
NM_198412

RefSeq (protein)

NP_001243793
NP_001243794
NP_055602

NP_001158055
NP_001158056
NP_001158057
NP_940804

Location (UCSC) Chr 1: 65.25 – 65.42 Mb Chr 4: 101.5 – 101.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[3][4][5]

Function[edit]

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[5]

Structure[edit]

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[6] The phosphatase domain belongs to the auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive. [7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. PMID 9455484. doi:10.1093/dnares/4.5.345. 
  4. ^ Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. PMC 312896Freely accessible. PMID 11147971. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. 
  5. ^ a b "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6". 
  6. ^ Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. PMC 4420535Freely accessible. PMID 25694109. doi:10.1002/pro.2664. 
  7. ^ Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474): eaag1796. PMID 28400531. doi:10.1126/scisignal.aag1796. 

External links[edit]

Further reading[edit]