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Clinical data
Trade names Optimine
AHFS/ Micromedex Detailed Consumer Information
  • US: B (No risk in non-human studies)
ATC code
CAS Number
PubChem CID
Chemical and physical data
Formula C20H22N2
Molar mass 290.402 g/mol
3D model (Jmol)

Azatadine (Optimine) is a first-generation antihistamine and anticholinergic that was launched Schering-Plough in 1973.[1][2]

It was patented in 1967.[3] It has been succeeded by other antihistamines[4]:53 and marketing approvals have been widely withdrawn.[5][6][7][8]:290[9]

See also[edit]


  1. ^ Katelaris, C. (1990). "Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis". Asian Pacific Journal of Allergy and Immunology. 8 (2): 103–107. PMID 1982614. 
  2. ^ Small, P.; Barrett, D.; Biskin, N. (1990). "Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation". Annals of Allergy. 64 (2 Pt 1): 129–131. PMID 1968324. 
  3. ^ Azatadine, Villani, F. J.; Caldwell, W. U.S. Patent 3,326,924 (1967).
  4. ^ Horak F. Antialergic and Vasoactive Drugs for Allergic Rhinitis. Chapter 4 in Allergy Frontiers:Therapy and Prevention. Volume 5 of Allergy Frontiers. Eds Pawankar R et al Springer Science & Business Media, 2010 ISBN 9784431993629
  5. ^ listing for Azatadine Page accessed July 3, 2015
  6. ^ Federal Register 2005 Food and Drug Administration Docket No.2005N-0058: Hospira, Inc. et al.; Withdrawal of Approval of 76 New Drug Applications and 60 Abbreviated New Drug Applications 70 FR 10651
  7. ^ Federal Register 2007 Food and Drug Administration Docket No. 2004P-0262: Withdrawal of Approval of 128 Suitability Petitions 72 FR 8184
  8. ^ Department of Economic and Social Affairs of the United Nations Secretariat Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals United Nations – New York, 2005
  9. ^ FDA OGD Suitability Tracking Report (Sorted by Drug Name) Page accessed July 3, 2015