Bifidobacterium breve

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Bifidobacterium breve
Scientific classification edit
Domain: Bacteria
Phylum: Actinomycetota
Class: Actinomycetia
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
B. breve
Binomial name
Bifidobacterium breve
Reuter 1963 (Approved Lists 1980)

Bifidobacterium breve is a bacterial species of the genus Bifidobacterium which has probiotic properties.[1][2] Bifidobacteria are a type of bacteria that live symbiotically in the intestines of humans. They have been used to treat a number of conditions including constipation, diarrhea, irritable bowel syndrome and even the cold and flu. Some of these uses have been backed up by scientific research, but others have not.[3] B. breve is a gram positive, anaerobic, rod shaped organism that is non motile and forms branches with its neighbors.[4]

Clinical Uses[edit]

B. breve has been researched and linked to a number of conditions. Bifidobacterium breve administered in combination with prebiotics or other probiotics and standard therapy has shown some beneficial effect.[5] B. breve is a constituent in the therapeutic, nutritional treatment of IBD. This proprietary, standardized, formulation of live bacteria is used to treat ulcerative colitis and may require a prescription.[5][6] Taking Bifidobacteria in combination with Lactobacillus and normal Helicobacter pylori therapy makes the treatment twice as effective while reducing the negative side effects. Bifidobacteria can also be used to treat IBS as well, reducing pain, bloating and constipation.[3]

B. breve may be linked to chronic obesity. A growing pool of evidence suggests that variations in the human gut microbiome correlate with excess weight gain. B.breve is a strong candidate for research concerning this issue. A study conducted by Bioscience of Microbiota, Food and Heath(BMFH) suggests that treating pre-obese patients with the B-3 strain of B. breve may stop or reverse obesity.[7] However larger studies need to be performed to confirm these results.

Bifidobacteria and its link to stomach health are being researched along with its link to the brain through the microbiota gut–brain axis. Strain A1 of B. Breve has undergone research concerning its effect on Alzheimer's. This research has consisted of mouse trials, and to date, shows promise in slowing or reversing the disease.[8]


B. breve strains were originally isolated from the feces of human infants.[9] In 1971, Bifidobacterium parvulorum and Bifidobacterium breve were merged under the name Bifidobacterium breve.[9] Bifidobacterium breve administered in combination with prebiotics, probiotics and standard therapy has showed some beneficial effect on gut health.[5] B. breve is a constituent in the therapeutic, nutritional treatment of IBD. This proprietary, standardized, formulation of live bacteria is used to treat ulcerative colitis and may require a prescription.[5][6]


B. breve strains can ferment mannitol and sorbitol, but not arabinose or xylose.[9]


  1. ^ Lyra, A.; Krogius-Kurikka, L.; Nikkilä, J.; Malinen, E.; Kajander, K.; Kurikka, K.; Korpela, R.; Palva, A. (2010). "Effect of a multispecies probiotic supplement on quantity of irritable bowel syndrome-related intestinal microbial phylotypes. It has a lot of probiotic advantages". BMC Gastroenterol. 10: 110. doi:10.1186/1471-230X-10-110. PMC 2949774. PMID 20849659.
  2. ^ Tabbers, M.; de Milliano, I.; Roseboom, M.; Benninga, M. (2011). "Is Bifidobacterium breve effective in the treatment of childhood constipation? Results from a pilot study". Nutrition Journal. 10: 19. doi:10.1186/1475-2891-10-19. PMC 3048518. PMID 21345213.
  3. ^ a b "Bifidobacteria: Uses, Side Effects, Interactions, Dosage, and Warning". Retrieved 2019-06-21.
  4. ^ Butta, Hena; Sardana, Raman; Vaishya, Raju; Singh, Kailash N; Mendiratta, Leena (2017). "Bifidobacterium: An Emerging Clinically Significant Metronidazole-resistant Anaerobe of Mixed Pyogenic Infections". Cureus. 9 (4): e1134. doi:10.7759/cureus.1134. ISSN 2168-8184. PMC 5418030. PMID 28480152.
  5. ^ a b c d Ghouri YA, Richards DM, Rahimi EF, Krill JT, Jelinek KA, DuPont AW (Dec 9, 2014). "Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease". Clin Exp Gastroenterol (Review). 7: 473–87. doi:10.2147/CEG.S27530. PMC 4266241. PMID 25525379.
  6. ^ a b Saez-Lara, Maria Jose; Gomez-Llorente, Carolina; Plaza-Diaz, Julio; Gil, Angel (2015). "The Role of Probiotic Lactic Acid Bacteria and Bifidobacteria in the Prevention and Treatment of Inflammatory Bowel Disease and Other Related Diseases: A Systematic Review of Randomized Human Clinical Trials". BioMed Research International. 2015: 1–15. doi:10.1155/2015/505878. ISSN 2314-6133. PMC 4352483. PMID 25793197.
  7. ^ Junichi, MINAMI (2018). "Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial". Bioscience of Microbiota, Food and Health. 37 (3): 67–75. doi:10.12938/bmfh.18-001. PMC 6081611. PMID 30094122.
  8. ^ Xiao, Jin-zhong; Abe, Keiko; Kondo, Takashi; Yasuoka, Akihito; Kuhara, Tetsuya; Mitsuyama, Eri; Shimada, Kousuke; Sugahara, Hirosuke; Kobayashi, Yodai (2017-10-18). "Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease". Scientific Reports. 7 (1): 13510. Bibcode:2017NatSR...713510K. doi:10.1038/s41598-017-13368-2. ISSN 2045-2322. PMC 5647431. PMID 29044140.
  9. ^ a b c Scardovi V; Trovatelli LD; Zani G; Crociani F; Matteuzzi D (October 1971). "Deoxyribonucleic Acid Homology Relationships Among Species of the Genus Bifidobacterium". Int J Syst Evol Microbiol. 21 (4): 276–294. doi:10.1099/00207713-21-4-276.

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