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Protein B3GAT2 PDB 2d0j.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases B3GAT2, GLCATS, beta-1,3-glucuronyltransferase 2
External IDs MGI: 2389490 HomoloGene: 50574 GeneCards: B3GAT2
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 70.86 – 70.96 Mb Chr 1: 23.76 – 23.85 Mb
PubMed search [1] [2]
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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.[3][4]

The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.[4]

Use of HNK-1 Antibody for Neural Crest Research[edit]

Antibodies raised against the HNK-1 epitope have played a large role in studies of the neural crest, especially in the avian embryo.[5] The first antibody raised against this epitope was NC-1,[6] which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope". Gene. 296 (1-2): 29–36. PMID 12383500. doi:10.1016/S0378-1119(02)00840-5. 
  4. ^ a b "Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)". 
  5. ^ Bronner-Fraser M (May 1986). "Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1". Dev. Biol. 115 (1): 44–55. PMID 3516760. doi:10.1016/0012-1606(86)90226-5. 
  6. ^ Vincent M, Thiery JP (June 1984). "A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system". Dev. Biol. 103 (2): 468–81. PMID 6202575. doi:10.1016/0012-1606(84)90334-8. 

External links[edit]

Further reading[edit]