|This article is an orphan, as no other articles link to it. Please introduce links to this page from ; try the Find link tool for suggestions. (May 2016)|
crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits, this family is called the B56 family.
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism such as DNA replication, transcription, translation, cell cycle, development, and apoptosis.
In order to exhibit specificity control over catalysis, hetero-oligomers are formed so the catalytic subunits are complexed with regulatory subunits. This helps direct their action towards the cellular substrate. This is the function of the B56 domain.
B56 alpha, is additionally thought to play a role in nuclear export.
Regulatory B subunit is a heterotrimer.
Mainly found in the cytoplasm, however various isoforms can be found in the nucleus.
Isoforms of B56 protein family
- McCright B, Virshup DM (November 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem. 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- Magnusdottir A, Stenmark P, Flodin S, Nyman T, Kotenyova T, Gräslund S, et al. (2009). "The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.". Proteins. 74 (1): 212–21. doi:10.1002/prot.22150. PMID 18618707.
- Flegg CP, Sharma M, Medina-Palazon C, Jamieson C, Galea M, Brocardo MG, et al. (2010). "Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit.". J Biol Chem. 285 (24): 18144–54. doi:10.1074/jbc.M109.093294. PMC . PMID 20378546.