CD276

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CD276
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, CD276 molecule
External IDsMGI: 2183926 HomoloGene: 11892 GeneCards: CD276
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CD276
Genomic location for CD276
Band15q24.1Start73,683,966 bp[1]
End73,714,518 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024736
NM_025240
NM_001329628
NM_001329629

NM_133983

RefSeq (protein)

NP_001019907
NP_001316557
NP_001316558
NP_079516

NP_598744

Location (UCSC)Chr 15: 73.68 – 73.71 MbChr 9: 58.52 – 58.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[5]

Function[edit]

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][5]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.[6]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]