BACH1

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BACH1
Protein BACH1 PDB 2ihc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BACH1, BACH-1, BTBD24, BTB domain and CNC homolog 1
External IDs MGI: 894680 HomoloGene: 916 GeneCards: 571
Genetically Related Diseases
Disease Name References
pancreatic cancer
RNA expression pattern
PBB GE BACH1 204194 at tn.png

PBB GE BACH1 210818 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001011545
NM_001186
NM_206866

NM_007520

RefSeq (protein)

NP_001177.1
NP_996749.1

NP_031546.1

Location (UCSC) Chr 21: 29.19 – 29.63 Mb Chr 16: 87.7 – 87.73 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.[1][2][3]

Function[edit]

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.[3]

References[edit]

  1. ^ Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE (Mar 1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics 102 (3): 282–8. doi:10.1007/s004390050692. PMID 9544839. 
  2. ^ Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O (Jan 1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics 47 (2): 300–6. doi:10.1006/geno.1997.5080. PMID 9479503. 
  3. ^ a b "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.