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BTB and CNC homology 1, basic leucine zipper transcription factor 1
Protein BACH1 PDB 2ihc.png
PDB rendering based on 2ihc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BACH1 ; BACH-1; BTBD24
External IDs OMIM602751 MGI894680 HomoloGene916 GeneCards: BACH1 Gene
RNA expression pattern
PBB GE BACH1 204194 at tn.png
PBB GE BACH1 210818 s at tn.png
More reference expression data
Species Human Mouse
Entrez 571 12013
Ensembl ENSG00000156273 ENSMUSG00000025612
UniProt O14867 P97302
RefSeq (mRNA) NM_001011545 NM_007520
RefSeq (protein) NP_001177 NP_031546
Location (UCSC) Chr 21:
29.19 – 29.63 Mb
Chr 16:
87.7 – 87.73 Mb
PubMed search [1] [2]

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.[1][2][3]


This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.[3]


  1. ^ Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE (Mar 1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics 102 (3): 282–8. doi:10.1007/s004390050692. PMID 9544839. 
  2. ^ Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O (Jan 1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics 47 (2): 300–6. doi:10.1006/geno.1997.5080. PMID 9479503. 
  3. ^ a b "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.