BAPTA

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BAPTA
Skeletal formula of BAPTA
Ball-and-stick model of the BAPTA molecule
Names
IUPAC name
1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
Identifiers
85233-19-8 N
ChEBI CHEBI:60888 YesY
ChemSpider 94562 YesY
Jmol 3D model Interactive image
PubChem 104751
Properties
C22H24N2O10
Molar mass 476.433
Density 1.494 g/cm3
Melting point 177 to 179 °C (351 to 354 °F; 450 to 452 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is a calcium-specific aminopolycarboxylic acid. The presence of four carboxylic acid functional groups makes possible the binding of two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions.

There is a range of reported values for the dissociation constant of BAPTA, though 0.2 µM appears consistently.[1] The rate constant for calcium binding is 500 µM−1 s−1.[1]

See also[edit]

References[edit]

  1. ^ a b Ricci AJ, Wu YC, Fettiplace R (15 October 1998). "The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.". The Journal of Neuroscience. 18 (20): 8261–77. PMID 9763471.