BATF (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Basic leucine zipper transcription factor, ATF-like
Symbols BATF ; B-ATF; BATF1; SFA-2; SFA2
External IDs OMIM612476 MGI1859147 HomoloGene4666 GeneCards: BATF Gene
RNA expression pattern
PBB GE BATF 205965 at tn.png
More reference expression data
Species Human Mouse
Entrez 10538 53314
Ensembl ENSG00000156127 ENSMUSG00000034266
UniProt Q16520 O35284
RefSeq (mRNA) NM_006399 NM_016767
RefSeq (protein) NP_006390 NP_058047
Location (UCSC) Chr 14:
75.99 – 76.01 Mb
Chr 12:
85.69 – 85.71 Mb
PubMed search [1] [2]

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[1][2][3]


The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[3]

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[4]


BATF (gene) has been shown to interact with IFI35.[5]


  1. ^ Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (December 1995). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene 11 (11): 2255–65. PMID 8570175. 
  2. ^ Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063. 
  3. ^ a b "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". 
  4. ^ Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B et al. (July 2009). "The AP-1 transcription factor Batf controls TH17 differentiation". Nature 460 (7253): 405–9. doi:10.1038/nature08114. PMC 2716014. PMID 19578362. Lay (2009-07-16). 
  5. ^ Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.