BCAR3

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BCAR3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BCAR3, NSP2, SH2D3B, breast cancer anti-estrogen resistance 3
External IDs MGI: 1352501 HomoloGene: 31181 GeneCards: BCAR3
RNA expression pattern
PBB GE BCAR3 204032 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261408
NM_001261409
NM_001261410
NM_001308251
NM_003567

NM_013867

RefSeq (protein)

NP_001248337
NP_001248338
NP_001248339
NP_001295180
NP_003558

NP_038895.1
NP_038895

Location (UCSC) Chr 1: 93.56 – 93.85 Mb Chr 3: 122.29 – 122.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[3][4]

Function[edit]

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[4]

References[edit]

External links[edit]

Further reading[edit]