BCAS1

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BCAS1
Identifiers
Aliases BCAS1, AIBC1, NABC1, breast carcinoma amplified sequence 1
External IDs MGI: 1924210 HomoloGene: 2714 GeneCards: BCAS1
RNA expression pattern
PBB GE BCAS1 204378 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003657
NM_001316361
NM_001323347

NM_001164369
NM_029815

RefSeq (protein)

NP_001303290
NP_001310276
NP_003648

NP_084091.2
NP_001157841
NP_084091

Location (UCSC) Chr 20: 53.94 – 54.07 Mb Chr 2: 170.35 – 170.43 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.[3][4]

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Aug 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140Freely accessible. PMID 9671742. 
  4. ^ a b "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1". 

External links[edit]

Further reading[edit]