BCAS3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
BCAS3
Identifiers
Aliases BCAS3, GAOB1, MAAB, breast carcinoma amplified sequence 3, microtubule associated cell migration factor
External IDs MGI: 2385848 HomoloGene: 9778 GeneCards: BCAS3
Genetically Related Diseases
Alzheimer's disease, obesity, smallpox[1]
RNA expression pattern
PBB GE BCAS3 220488 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099432
NM_017679
NM_001320470
NM_001330413
NM_001330414

NM_001166642
NM_001166643
NM_138681

RefSeq (protein)

NP_001092902
NP_001307399
NP_001317342
NP_001317343
NP_060149

NP_001160114.1
NP_619622.3
NP_001160114
NP_001160115
NP_619622

Location (UCSC) Chr 17: 60.68 – 61.39 Mb Chr 11: 85.35 – 85.83 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[4][5] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[5]

Function[edit]

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[6] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[7] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with BCAS3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3". 
  5. ^ a b Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. 
  6. ^ Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. doi:10.1073/pnas.0601989103. PMC 1458939Freely accessible. PMID 16617102. 
  7. ^ a b Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058. 

External links[edit]

Further reading[edit]