BCCIP

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BCCIP
Identifiers
AliasesBCCIP, TOK-1, TOK1, BRCA2 and CDKN1A interacting protein
External IDsOMIM: 611883 MGI: 1913415 HomoloGene: 41629 GeneCards: BCCIP
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for BCCIP
Genomic location for BCCIP
Band10q26.2Start125,823,546 bp[1]
End125,853,695 bp[1]
RNA expression pattern
PBB GE BCCIP 218264 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_078469
NM_016567
NM_078468

NM_025392

RefSeq (protein)

NP_057651
NP_510868
NP_510869

NP_079668

Location (UCSC)Chr 10: 125.82 – 125.85 MbChr 7: 133.71 – 133.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BRCA2 and CDKN1A-interacting protein is a protein that in humans is encoded by the BCCIP gene.[5][6][7]

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]

Interactions[edit]

BCCIP has been shown to interact with BRCA2,[5] P21,[6] and PTPmu (PTPRM)[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107949 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030983 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Liu J, Yuan Y, Huan J, Shen Z (Apr 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2". Oncogene. 20 (3): 336–45. doi:10.1038/sj.onc.1204098. PMID 11313963.
  6. ^ a b Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000). "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase". J Biol Chem. 275 (40): 31145–54. doi:10.1074/jbc.M003031200. PMID 10878006.
  7. ^ a b "Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein".
  8. ^ Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM (2008). "BCCIP associates with the receptor protein tyrosine phosphatase PTPmu". J Cell Biochem. 105 (4): 1059–72. doi:10.1002/jcb.21907. PMC 2758318. PMID 18773424.

External links[edit]

Further reading[edit]