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External IDs GeneCards: [1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



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View/Edit Human

B-cell growth factor 1, 12kDa, also known as BCGF1, is a human gene.[1]


B-cell growth factor is released by T lymphocytes after either lectin or antigen stimulation. It supports the clonal proliferation of B lymphocytes.[1]


Further reading[edit]

  • Kumar A, Vasquez A, Maizel AL, Sharma S (1991). "Human BCGF-12kD functions as an autocrine growth factor in transformed B cells". European Cytokine Network. 1 (2): 109–13. PMID 1966378. 
  • Vazquez A, Mills S, Sharma S, Maizel AL (October 1988). "Expression of CD23 antigen is not necessary for human 12-kDa B cell growth factor-mediated B cell proliferation". European Journal of Immunology. 18 (10): 1647–9. doi:10.1002/eji.1830181029. PMID 2973416. 
  • Mehta SR, Sandler RS, Ford RJ, Sharma S, Maizel AL (1986). "Cellular interaction between B and T lymphocytes: enhanced release of B cell growth factor". Lymphokine Research. 5 (1): 49–57. PMID 3484798. 
  • Ennist DL, Greenblatt D, Coffman R, Sharma S, Maizel A, Howard M (November 1987). "Activity of a partially purified human BCGF on murine assays for B-cell stimulatory factors. I. BCGF II-like activity of human BCGF". Cellular Immunology. 110 (1): 77–94. doi:10.1016/0008-8749(87)90103-1. PMID 3499989. 
  • Sharma S, Mehta S, Morgan J, Maizel A (March 1987). "Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli". Science. 235 (4795): 1489–92. doi:10.1126/science.3547651. PMID 3547651. 
  • Sahasrabuddhe CG, Morgan J, Sharma S, Mehta S, Martin B, Wright D, Maizel A (December 1984). "Evidence for an intracellular precursor for human B-cell growth factor". Proceedings of the National Academy of Sciences of the United States of America. 81 (24): 7902–6. doi:10.1073/pnas.81.24.7902. PMC 392261Freely accessible. PMID 6083564. 
  • Kovanen PE, Virtaneva K, Harju L, Kantor C, Gahmberg CG, Timonen T (March 1995). "Expression and characterization of a B cell growth promoting polypeptide derived from the 12 kDa B cell growth factor gene (BCGF 1)". FEBS Letters. 361 (2-3): 233–7. doi:10.1016/0014-5793(95)00186-D. PMID 7698329. 
  • Zietkiewicz E, Makałowski W, Mitchell GA, Labuda D (August 1994). "Phylogenetic analysis of a reported complementary DNA sequence". Science. 265 (5175): 1110–1. doi:10.1126/science.8066452. PMID 8066452. 
  • Kovanen PE, Harju L, Timonen T (October 1996). "Complementary DNA for 12-kilodalton B cell growth factor: misassigned". Science. 274 (5287): 629–31. doi:10.1126/science.274.5287.629. PMID 8928011. 
  • Zietkiewicz E, Makałowski W, Mitchell G, Labuda D (October 1996). "Complementary DNA for 12-kilodalton B cell growth factor: misassigned". Science. 274 (5287): 631; author reply 631. doi:10.1126/science.274.5287.631a. PMID 8928012.