BCL2-like 1 (gene)

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BCL2-like 1
Protein BCL2L1 PDB 1af3.png
PDB rendering based on 1af3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL2L1 ; BCL-XL/S; BCL2L; BCLX; BCLXL; BCLXS; Bcl-X; PPP1R52; bcl-xL; bcl-xS
External IDs OMIM600039 MGI88139 HomoloGene7639 ChEMBL: 4625 GeneCards: BCL2L1 Gene
RNA expression pattern
PBB GE BCL2L1 212312 at tn.png
PBB GE BCL2L1 206665 s at tn.png
PBB GE BCL2L1 215037 s at tn.png
More reference expression data
Species Human Mouse
Entrez 598 12048
Ensembl ENSG00000171552 ENSMUSG00000007659
UniProt Q07817 Q64373
RefSeq (mRNA) NM_001191 NM_001289716
RefSeq (protein) NP_001182 NP_001276645
Location (UCSC) Chr 20:
31.66 – 31.72 Mb
Chr 2:
152.78 – 152.83 Mb
PubMed search [1] [2]

Bcl-2-like protein 1 is a protein that in humans is encoded by the BCL2L1 gene.[1]


The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species(ROS) and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.[2][3]

A LncRNA (Long non coding RNA, a RNA that acts without coding a protein) is involved with the alternative splicing between the two isoforms (BCL-XL and BCL-XS). This LncRNA is called INXS[4][5] and acts as a pro-apoptotic agent, been downregulated in cancer cells.[4]


BCL2-like 1 (gene) has been shown to interact with:


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Further reading[edit]