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Available structures
PDB Ortholog search: PDBe RCSB
Aliases BCL2L10, BCL-B, Boo, Diva, bcl2-L-10, BCL2 like 10
External IDs MGI: 1330841 HomoloGene: 8396 GeneCards: BCL2L10
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for BCL2L10
Genomic location for BCL2L10
Band 15q21.2 Start 52,109,263 bp[1]
End 52,112,775 bp[1]
RNA expression pattern
PBB GE BCL2L10 221320 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 52.11 – 52.11 Mb Chr 9: 75.35 – 75.35 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.[5][6][7]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137875 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032191 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nunez G (Jan 1999). "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death". J Biol Chem. 273 (49): 32479–86. doi:10.1074/jbc.273.49.32479. PMID 9829980. 
  6. ^ Song Q, Kuang Y, Dixit VM, Vincenz C (Feb 1999). "Boo, a novel negative regulator of cell death, interacts with Apaf-1". EMBO J. 18 (1): 167–78. doi:10.1093/emboj/18.1.167. PMC 1171112Freely accessible. PMID 9878060. 
  7. ^ a b "Entrez Gene: BCL2L10 BCL2-like 10 (apoptosis facilitator)". 

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