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BCL2-like 11 (apoptosis facilitator)
Protein BCL2L11 PDB 2K7W.png
Rendering based on PDB 2K7W.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL2L11 ; BAM; BIM; BOD
External IDs OMIM603827 MGI1197519 HomoloGene7643 ChEMBL: 5777 GeneCards: BCL2L11 Gene
RNA expression pattern
PBB GE BCL2L11 208536 s at tn.png
PBB GE BCL2L11 222343 at tn.png
More reference expression data
Species Human Mouse
Entrez 10018 12125
Ensembl ENSG00000153094 ENSMUSG00000027381
UniProt O43521 O54918
RefSeq (mRNA) NM_001204106 NM_001284410
RefSeq (protein) NP_001191035 NP_001271339
Location (UCSC) Chr 2:
111.12 – 111.17 Mb
Chr 2:
128.13 – 128.16 Mb
PubMed search [1] [2]

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.[1][2]


The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.[3]


BCL2L11 has been shown to interact with:

See also[edit]


  1. ^ a b c d e Hsu SY, Lin P, Hsueh AJ (November 1998). "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Mol Endocrinol 12 (9): 1432–40. doi:10.1210/mend.12.9.0166. PMID 9731710. 
  2. ^ a b c d O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC (February 1998). "Bim: a novel member of the Bcl-2 family that promotes apoptosis". EMBO J 17 (2): 384–95. doi:10.1093/emboj/17.2.384. PMC 1170389. PMID 9430630. 
  3. ^ "Entrez Gene: BCL2L11 BCL2-like 11 (apoptosis facilitator)". 
  4. ^ a b c Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 
  5. ^ Whitfield J, Harada K, Bardelle C, Staddon JM (November 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. 322 (2): 170–8. doi:10.1016/j.ab.2003.07.014. PMID 14596824. 
  6. ^ Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217. 
  7. ^ Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, Kumar R (June 2004). "Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes". Cancer Cell 5 (6): 575–85. doi:10.1016/j.ccr.2004.05.022. PMID 15193260. 
  8. ^ Bae J, Leo CP, Hsu SY, Hsueh AJ (August 2000). "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. 275 (33): 25255–61. doi:10.1074/jbc.M909826199. PMID 10837489. 

Further reading[edit]

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