BCL3

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For BCl3, see Boron trichloride.
BCL3
Protein BCL3 PDB 1k1a.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3
External IDs MGI: 88140 HomoloGene: 81738 GeneCards: BCL3
RNA expression pattern
PBB GE BCL3 204907 s at tn.png

PBB GE BCL3 204908 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005178

NM_033601

RefSeq (protein)

NP_005169.2

NP_291079.2

Location (UCSC) Chr 19: 44.75 – 44.76 Mb Chr 7: 19.81 – 19.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.[3][4]

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.[5]

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.

Interactions[edit]

BCL3 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wulczyn FG, Naumann M, Scheidereit C (Sep 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–9. doi:10.1038/358597a0. PMID 1501714. 
  4. ^ Ohno H, Takimoto G, McKeithan TW (May 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–7. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. 
  5. ^ "Entrez Gene: BCL3 B-cell CLL/lymphoma 3". 
  6. ^ a b c d Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352. 
  7. ^ a b c Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (Oct 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212. 
  8. ^ "Molecular Interaction Database". 
  9. ^ a b Thornburg NJ, Pathmanathan R, Raab-Traub N (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. 63 (23): 8293–301. PMID 14678988. 
  10. ^ Naumann M, Wulczyn FG, Scheidereit C (January 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. 12 (1): 213–22. PMC 413194Freely accessible. PMID 8428580. 
  11. ^ Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (Sep 1999). "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes". EMBO J. 18 (17): 4766–78. doi:10.1093/emboj/18.17.4766. PMC 1171549Freely accessible. PMID 10469655. 
  12. ^ Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (Mar 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell. 72 (5): 729–39. doi:10.1016/0092-8674(93)90401-b. PMID 8453667. 
  13. ^ Na SY, Choi HS, Kim JW, Na DS, Lee JW (Nov 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". J. Biol. Chem. 273 (47): 30933–8. doi:10.1074/jbc.273.47.30933. PMID 9812988. 

Further reading[edit]

External links[edit]