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Protein BCL3 PDB 1k1a.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesBCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
External IDsOMIM: 109560 MGI: 88140 HomoloGene: 81738 GeneCards: BCL3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for BCL3
Genomic location for BCL3
Band19q13.32Start44,747,705 bp[1]
End44,760,044 bp[1]
RNA expression pattern
PBB GE BCL3 204908 s at fs.png

PBB GE BCL3 204907 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 44.75 – 44.76 MbChr 7: 19.81 – 19.82 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.[5][6]

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.[7]

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.


BCL3 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069399 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053175 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wulczyn FG, Naumann M, Scheidereit C (Sep 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–9. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.
  6. ^ Ohno H, Takimoto G, McKeithan TW (May 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–7. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.
  7. ^ "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".
  8. ^ a b c d Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
  9. ^ a b c Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (Oct 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212.
  10. ^ "Molecular Interaction Database". Archived from the original on 2006-05-06. Retrieved 2012-05-08.
  11. ^ a b Thornburg NJ, Pathmanathan R, Raab-Traub N (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. 63 (23): 8293–301. PMID 14678988.
  12. ^ Naumann M, Wulczyn FG, Scheidereit C (January 1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. 12 (1): 213–22. doi:10.1002/j.1460-2075.1993.tb05647.x. PMC 413194. PMID 8428580.
  13. ^ Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (Sep 1999). "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes". EMBO J. 18 (17): 4766–78. doi:10.1093/emboj/18.17.4766. PMC 1171549. PMID 10469655.
  14. ^ Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (Mar 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell. 72 (5): 729–39. doi:10.1016/0092-8674(93)90401-b. PMID 8453667.
  15. ^ Na SY, Choi HS, Kim JW, Na DS, Lee JW (Nov 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". J. Biol. Chem. 273 (47): 30933–8. doi:10.1074/jbc.273.47.30933. PMID 9812988.

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