The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several coreتترمنتpressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL), and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain.
Physiologically, BCL6 is a master transcription factor which leads the differentiation of naive helper T cells in Follicular Helper T cells (TFH cells). Its action is negatively regulated by the gene PRDM1 encoding the transcription factor Blimp-1.
^Vasanwala FH, Kusam S, Toney LM, Dent AL (August 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". J. Immunol.169 (4): 1922–9. doi:10.4049/jimmunol.169.4.1922. PMID12165517.
^David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID9627120.
^ abcLemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem.277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID11929873.
^Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem.273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID9765306.
^Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID9927193.
^Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH (December 2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene19 (54): 6240–50. doi:10.1038/sj.onc.1203976. PMID11175338.
Jardin F, Ruminy P, Bastard C, Tilly H (2007). "The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis". Pathol. Biol.55 (1): 73–83. doi:10.1016/j.patbio.2006.04.001. PMID16815642.