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B-cell CLL/lymphoma 6
Protein BCL6 PDB 1r28.png
PDB rendering based on 1r28.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BCL6 ; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
External IDs OMIM109565 MGI107187 HomoloGene7640 GeneCards: BCL6 Gene
RNA expression pattern
PBB GE BCL6 203140 at tn.png
PBB GE BCL6 215990 s at tn.png
More reference expression data
Species Human Mouse
Entrez 604 12053
Ensembl ENSG00000113916 ENSMUSG00000022508
UniProt P41182 P41183
RefSeq (mRNA) NM_001130845 NM_009744
RefSeq (protein) NP_001124317 NP_033874
Location (UCSC) Chr 3:
187.72 – 187.75 Mb
Chr 16:
23.97 – 23.99 Mb
PubMed search [1] [2]

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.[1] Like BCL2, BCL3, BCL5, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.


The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several corepressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL),[2][3][4] and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain.[5]

Physiologically, BCL6 is a master transcription factor which leads the differentiation of naive helper T cells in Follicular Helper T cells (TFH cells).[6] Its action is negatively regulated by the gene PRDM1 encoding the transcription factor Blimp-1.[7]

Diagnostic utility[edit]

The presence of BCL6 can be demonstrated in tissue sections using immunohistochemistry. It is exclusively present in the B-cells of both healthy and neoplastic germinal centres. It therefore demonstrates both reactive hyperplasia in lymph nodes and a range of lymphomas derived from follicular B-cells, such as Burkitt's lymphoma, follicular lymphoma, and the nodular lymphocyte predominant subtype of Hodgkin's disease. It is often used together with antibodies to Bcl-2 antigen to distinguish neoplastic follicles from those found in benign hyperplasia, for which Bcl-2 is negative.[8]


BCL6 has been shown to interact with


  1. ^ "Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)". 
  2. ^ Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (October 1993). "Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma". Science 262 (5134): 747–50. doi:10.1126/science.8235596. PMID 8235596. 
  3. ^ Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C (September 1993). "LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas". Nat. Genet. 5 (1): 66–70. doi:10.1038/ng0993-66. PMID 8220427. 
  4. ^ Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (December 1995). "Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12520–4. doi:10.1073/pnas.92.26.12520. PMC 40389. PMID 8618933. 
  5. ^ Shen Y, Ge B, Ramachandrareddy H, McKeithan T, Chan WC (October 2008). "Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor". Biochem. Biophys. Res. Commun. 375 (2): 190–3. doi:10.1016/j.bbrc.2008.07.116. PMC 2573862. PMID 18675787. 
  6. ^ Roza I. Nurieva, Yeonseok Chung, Gustavo J. Martinez, Xuexian O. Yang, Shinya Tanaka, Tatyana D. Matskevitch, Yi-Hong Wang, Chen Dong (August 2009). "Bcl6 Mediates the Development of T Follicular Helper Cells". Science 325 (5943): 1001–1005. doi:10.1126/science.1176676. PMID 19628815. 
  7. ^ Robert J. Johnston, Amanda C. Poholek, Daniel DiToro, Isharat Yusuf, Danelle Eto, Burton Barnett, Alexander L. Dent, Joe Craft, Shane Crotty (August 2009). "Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation". Science 325 (5943): 1006–1010. doi:10.1126/science.1175870. PMID 19608860. 
  8. ^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 29. ISBN 1-84110-100-1. 
  9. ^ a b Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795. 
  10. ^ Vasanwala FH, Kusam S, Toney LM, Dent AL (August 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". J. Immunol. 169 (4): 1922–9. doi:10.4049/jimmunol.169.4.1922. PMID 12165517. 
  11. ^ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120. 
  12. ^ a b Deltour S, Guerardel C, Leprince D (December 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831–6. doi:10.1073/pnas.96.26.14831. PMC 24733. PMID 10611298. 
  13. ^ a b c Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873. 
  14. ^ Gupta S, Jiang M, Anthony A, Pernis AB (December 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMC 2195723. PMID 10601358. 
  15. ^ Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306. 
  16. ^ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193. 
  17. ^ Oestreich KJ, Huang AC, Weinmann AS (May 2011). "The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns". J. Exp. Med. 208 (5): 1001–13. doi:10.1084/jem.20102144. PMC 3092354. PMID 21518797. 
  18. ^ Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH (December 2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene 19 (54): 6240–50. doi:10.1038/sj.onc.1203976. PMID 11175338. 

Further reading[edit]

  • Ueda C, Akasaka T, Ohno H (2003). "Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications". Leuk. Lymphoma 43 (7): 1375–81. doi:10.1080/10428190290033305. PMID 12389616. 
  • Niu H (2003). "The proto-oncogene BCL-6 in normal and malignant B cell development". Hematological oncology 20 (4): 155–66. doi:10.1002/hon.689. PMID 12469325. 
  • Tokuhisa T (2003). "[A role for Bcl6 in immune memory development]". Tanpakushitsu Kakusan Koso 47 (16 Suppl): 2306–12. PMID 12518453. 
  • Ohno H (2004). "Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma". Histol. Histopathol. 19 (2): 637–50. PMID 15024721. 
  • Pasqualucci L, Bereschenko O, Niu H, et al. (2004). "Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6". Leuk. Lymphoma. 44 Suppl 3: S5–12. doi:10.1080/10428190310001621588. PMID 15202519. 
  • Jardin F, Ruminy P, Bastard C, Tilly H (2007). "The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis". Pathol. Biol. 55 (1): 73–83. doi:10.1016/j.patbio.2006.04.001. PMID 16815642. 

See also[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.