Available structures PDB Ortholog search: PDBe RCSB
List of PDB id codes 1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M Identifiers Aliases , BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor BCL6 External IDs OMIM: 109565 MGI: 107187 HomoloGene: 7640 GeneCards: BCL6
Gene location (Mouse) Chr. Chromosome 16 (mouse)  Band 16 B1|16 15.26 cM Start 23,965,052 bp  End 23,988,852 bp 
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • intronic transcription regulatory region sequence-specific DNA binding • chromatin binding • metal ion binding • GO:0001948 protein binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • chromatin DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • replication fork • cell nucleus • nucleoplasm • Golgi apparatus Biological process • regulation of germinal center formation • positive regulation of histone deacetylation • negative regulation of T-helper 2 cell differentiation • protein localization • negative regulation of mast cell cytokine production • regulation of transcription, DNA-templated • immune system process • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • regulation of transcription from RNA polymerase II promoter • negative regulation of cell differentiation • germinal center formation • negative regulation of Rho protein signal transduction • negative regulation of isotype switching to IgE isotypes • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • type 2 immune response • cellular response to DNA damage stimulus • negative regulation of cell-matrix adhesion • regulation of cell proliferation • positive regulation of B cell proliferation • negative regulation of cell growth • Rho protein signal transduction • cell morphogenesis • spermatogenesis • regulation of memory T cell differentiation • positive regulation of neuron differentiation • regulation of inflammatory response • regulation of immune response • positive regulation of apoptotic process • negative regulation of type 2 immune response • negative regulation of B cell apoptotic process • positive regulation of cellular component movement • B cell differentiation • inflammatory response • negative regulation of transcription, DNA-templated • actin cytoskeleton organization • negative regulation of cell proliferation • negative regulation of Notch signaling pathway • erythrocyte development • negative regulation of cellular senescence • regulation of apoptotic process • negative regulation of mitotic cell cycle DNA replication • positive regulation of regulatory T cell differentiation • cytokine-mediated signaling pathway Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 3: 187.72 – 187.75 Mb Chr 16: 23.97 – 23.99 Mb PubMed search   Wikidata
B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene. Like  BCL2, BCL3, BCL5, BCL7A, BCL9 and BCL10, it has clinical significance in lymphoma.
Function [ edit ]
The protein encoded by this gene is an evolutionarily conserved
zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several corepressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL)   and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the  DNA binding domain.
Physiologically, BCL6 is a master transcription factor which leads the differentiation of naive helper T cells in
Follicular Helper T cells (TFH cells). Its action is negatively regulated by the gene  PRDM1 encoding the transcription factor Blimp-1.
Diagnostic utility [ edit ]
The presence of BCL6 can be demonstrated in tissue sections using
immunohistochemistry. It is exclusively present in the B-cells of both healthy and neoplastic germinal centres. It therefore demonstrates both reactive hyperplasia in lymph nodes and a range of lymphomas derived from follicular B-cells, such as Burkitt's lymphoma, follicular lymphoma and the nodular lymphocyte predominant subtype of Hodgkin's disease. It is often used together with antibodies to Bcl-2 antigen to distinguish neoplastic follicles from those found in benign hyperplasia, for which Bcl-2 is negative.
Interactions [ edit ]
BCL6 has been shown to
HDAC1,  
NCOR2,   
SMRT,  
T-bet,  ZBTB16 
See also [ edit ]
References [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000113916 - Ensembl, May 2017
^ a b c
GRCm38: Ensembl release 89: ENSMUSG00000022508 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)".
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (October 1993). "Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma". Science. 262 (5134): 747–50. doi: 10.1126/science.8235596. PMID 8235596.
Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C (September 1993). "LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas". Nature Genetics. 5 (1): 66–70. doi: 10.1038/ng0993-66. PMID 8220427.
Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (December 1995). "Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 92 (26): 12520–4. doi: 10.1073/pnas.92.26.12520. PMC . 40389 PMID 8618933.
Shen Y, Ge B, Ramachandrareddy H, McKeithan T, Chan WC (October 2008). "Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor". Biochemical and Biophysical Research Communications. 375 (2): 190–3. doi: 10.1016/j.bbrc.2008.07.116. PMC . 2573862 PMID 18675787.
Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C (August 2009). "Bcl6 mediates the development of T follicular helper cells". Science. 325 (5943): 1001–5. doi: 10.1126/science.1176676. PMC . 2857334 PMID 19628815.
Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S (August 2009). "Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation". Science. 325 (5943): 1006–10. doi: 10.1126/science.1175870. PMC . 2766560 PMID 19608860.
Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2nd ed.). Greenwich Medical Media, Ltd. p. 29. ISBN . 978-1-84110-100-2
^ a b
Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes & Development. 14 (14): 1810–23. doi: 10.1101/gad.14.14.1810 (inactive 2020-01-22). PMC . 316791 PMID 10898795.
Vasanwala FH, Kusam S, Toney LM, Dent AL (August 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". Journal of Immunology. 169 (4): 1922–9. doi: . 10.4049/jimmunol.169.4.1922 PMID 12165517.
^ a b
David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi: . 10.1038/sj.onc.1202043 PMID 9627120.
^ a b
Deltour S, Guerardel C, Leprince D (December 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14831–6. doi: 10.1073/pnas.96.26.14831. PMC . 24733 PMID 10611298.
^ a b c
Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". The Journal of Biological Chemistry. 277 (24): 22045–52. doi: . 10.1074/jbc.M201736200 PMID 11929873.
Gupta S, Jiang M, Anthony A, Pernis AB (December 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". The Journal of Experimental Medicine. 190 (12): 1837–48. doi: 10.1084/jem.190.12.1837. PMC . 2195723 PMID 10601358.
^ a b
Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry. 273 (42): 27695–702. doi: . 10.1074/jbc.273.42.27695 PMID 9765306.
Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi: . 10.1038/sj.onc.1202332 PMID 9927193.
Oestreich KJ, Huang AC, Weinmann AS (May 2011). "The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns". The Journal of Experimental Medicine. 208 (5): 1001–13. doi: 10.1084/jem.20102144. PMC . 3092354 PMID 21518797.
Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH (December 2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene. 19 (54): 6240–50. doi: . 10.1038/sj.onc.1203976 PMID 11175338.
Further reading [ edit ]
Ueda C, Akasaka T, Ohno H (July 2002). "Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications". Leukemia & Lymphoma. 43 (7): 1375–81. doi: 10.1080/10428190290033305. PMID 12389616.
Niu H (December 2002). "The proto-oncogene BCL-6 in normal and malignant B cell development". Hematological Oncology. 20 (4): 155–66. doi: 10.1002/hon.689. PMID 12469325.
Tokuhisa T (December 2002). "[A role for Bcl6 in immune memory development]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 47 (16 Suppl): 2306–12. PMID 12518453.
Ohno H (April 2004). "Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma". Histology and Histopathology. 19 (2): 637–50. PMID 15024721.
Pasqualucci L, Bereshchenko O, Bereschenko O, Niu H, Klein U, Basso K, Guglielmino R, Cattoretti G, Dalla-Favera R (2004). "Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6". Leukemia & Lymphoma. 44 Suppl 3: S5–12. doi: 10.1080/10428190310001621588. PMID 15202519. Jardin F, Ruminy P, Bastard C, Tilly H (February 2007). "The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis". Pathologie-Biologie. 55 (1): 73–83. doi: 10.1016/j.patbio.2006.04.001. PMID 16815642.
External links [ edit ]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.