BECN1

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BECN1
Protein BECN1 PDB 2p1l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BECN1, ATG6, VPS30, beclin1, beclin 1
External IDs MGI: 1891828 HomoloGene: 2794 GeneCards: BECN1
RNA expression pattern
PBB GE BECN1 208945 s at fs.png

PBB GE BECN1 208946 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001313998
NM_001313999
NM_001314000
NM_003766

NM_019584

RefSeq (protein)

NP_001300927
NP_001300928
NP_001300929
NP_003757

NP_062530.2
NP_062530

Location (UCSC) Chr 17: 42.81 – 42.83 Mb Chr 11: 101.29 – 101.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Beclin-1 is a protein that in humans is encoded by the BECN1 gene.[3][4] Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6)  and BEC-1 in the C. elegans nematode.[5] This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

Role in disease[edit]

Beclin-1 plays an important role in tumorigenesis, and neurodegeneration, being implicated in the autophagic programmed cell death.[6] Ovarian cancer with upregulated autophagy has a less aggressive behavior and is more responsive to chemotherapy.[7]

Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death.[8]

Interactions[edit]

BECN1 has been shown to interact with:

Modulators[edit]

Trehalose
Trehalose reduces p62/Beclin-1 ratio and increases autophagy in the frontal cortex of ICR mice, possibly by increasing Beclin-1.[11]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, Herman B, Levine B (Nov 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. PMC 110269Freely accessible. PMID 9765397. 
  4. ^ "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)". 
  5. ^ Takacs-Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, Kovacs AL, Müller F (Aug 2005). "Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans". Current Biology. 15 (16): 1513–7. doi:10.1016/j.cub.2005.07.035. PMID 16111945. 
  6. ^ Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z (Apr 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389Freely accessible. PMID 19270693. 
  7. ^ a b Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242Freely accessible. PMID 25136588. 
  8. ^ Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, Dean B, Levine J, Agam G, Gozes I (Feb 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMID 24365867. Lay summaryMediLexicon International Ltd. 
  9. ^ Erlich S, Mizrachy L, Segev O, Lindenboim L, Zmira O, Adi-Harel S, Hirsch JA, Stein R, Pinkas-Kramarski R (2007). "Differential interactions between Beclin 1 and Bcl-2 family members". Autophagy. 3 (6): 561–8. doi:10.4161/auto.4713. PMID 17643073. 
  10. ^ Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (Aug 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. 
  11. ^ Kara NZ, Toker L, Agam G, Anderson GW, Belmaker RH, Einat H (Sep 2013). "Trehalose induced antidepressant-like effects and autophagy enhancement in mice". Psychopharmacology. 229 (2): 367–75. doi:10.1007/s00213-013-3119-4. PMID 23644913. 

External links[edit]

Further reading[edit]