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BHFF structure.png
Systematic (IUPAC) name
CAS Registry Number 123557-91-5 YesY
PubChem CID: 4332683
ChemSpider 3537035 YesY
Chemical data
Formula C17H21F3O3
Molecular mass 330.341 g/mol
 YesY (what is this?)  (verify)

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and good oral bioavailability.[1]


  1. ^ Malherbe, P; Masciadri, R; Norcross, RD; Knoflach, F; Kratzeisen, C; Zenner, MT; Kolb, Y; Marcuz, A; Huwyler, J (2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC 2439845. PMID 18536733.