Class A basic helix-loop-helix protein 15

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BHLHA15
Identifiers
Aliases BHLHA15, BHLHB8, MIST1, basic helix-loop-helix family member a15
External IDs MGI: 891976 HomoloGene: 7838 GeneCards: BHLHA15
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_177455

NM_010800

RefSeq (protein)

NP_803238

NP_034930.1
NP_034930

Location (UCSC) Chr 7: 98.21 – 98.21 Mb Chr 5: 144.19 – 144.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, intestine and stomach expression 1 (MIST-1) is a protein that in humans is encoded by the BHLHA15 gene.[3][4][5]

Function[edit]

bHLHa15 is required developmentally for the proper organization of all protein secreting, serous exocrine glands. In the absence of Mist1, exocrine tissue shows improper organization of organelles, especially the localization of the zymogen granules. The zymogen granules are the vesicles that store enzymes near the plasma membrane for easy release when stimulated. This disorganization caused by the loss of Mist1 leads to increased susceptibility toward pancreatic damage and potentially pancreatic cancer.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McLellan AS, Langlands K, Kealey T (Sep 2003). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Mech Dev. 119 Suppl 1: S285–91. doi:10.1016/S0925-4773(03)00130-8. PMID 14516699. 
  4. ^ Stevens JD, Roalson EH, Skinner MK (Dec 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMID 18557763. 
  5. ^ "Entrez Gene: BHLHB8 basic helix-loop-helix domain containing, class B, 8". 

Further reading[edit]