BIRC6

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BIRC6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDs MGI: 1276108 HomoloGene: 7248 GeneCards: 57448
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016252

NM_007566

RefSeq (protein)

NP_057336.3

NP_031592.3

Location (UCSC) Chr 2: 32.36 – 32.62 Mb Chr 17: 74.53 – 74.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[1][2]

Function[edit]

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[2]

Interactions[edit]

BIRC6 has been shown to interact with KIF23.[3]

Diseases[edit]

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers [4] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology,[5]).

References[edit]

  1. ^ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019. 
  2. ^ a b "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)". 
  3. ^ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369. 
  4. ^ http://atlasgeneticsoncology.org/Genes/BIRC6ID798ch2p22.html
  5. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org. 

Further reading[edit]