BIRC6

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BIRC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDsMGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for BIRC6
Genomic location for BIRC6
Band2p22.3Start32,357,028 bp[1]
End32,618,899 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016252

NM_007566

RefSeq (protein)

NP_057336

NP_031592

Location (UCSC)Chr 2: 32.36 – 32.62 MbChr 17: 74.53 – 74.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[5][6]

Function[edit]

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[6]

Interactions[edit]

BIRC6 has been shown to interact with KIF23.[7]

Diseases[edit]

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology[9]).

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115760 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024073 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
  6. ^ a b "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
  7. ^ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369.
  8. ^ "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
  9. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

External links[edit]

Further reading[edit]