BIRC7

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BIRC7
Protein BIRC7 PDB 1oxn.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBIRC7, KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat containing 7
External IDsMGI: 2676458 HomoloGene: 51405 GeneCards: BIRC7
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for BIRC7
Genomic location for BIRC7
Band20q13.33Start63,235,883 bp[1]
End63,240,507 bp[1]
RNA expression pattern
PBB GE BIRC7 220451 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139317
NM_022161

NM_001163247

RefSeq (protein)

NP_071444
NP_647478

NP_001156719

Location (UCSC)Chr 20: 63.24 – 63.24 MbChr 2: 180.93 – 180.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.[5][6][7]

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.[7] In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101197 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038840 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kasof GM, Gomes BC (May 2001). "Livin, a novel inhibitor of apoptosis protein family member". J Biol Chem. 276 (5): 3238–46. doi:10.1074/jbc.M003670200. PMID 11024045. 
  6. ^ Lin JH, Deng G, Huang Q, Morser J (Feb 2001). "KIAP, a novel member of the inhibitor of apoptosis protein family". Biochem Biophys Res Commun. 279 (3): 820–31. doi:10.1006/bbrc.2000.4027. PMID 11162435. 
  7. ^ a b "Entrez Gene: BIRC7 baculoviral IAP repeat-containing 7 (livin)". 
  8. ^ Dynek JN, Chan SM, Liu J, et al. (2008). "Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas". Cancer Res. 68 (9): 3124–32. doi:10.1158/0008-5472.CAN-07-6622. PMID 18451137. 
  9. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

External links[edit]

Further reading[edit]