Tyrosine-protein kinase BLK

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BLK proto-oncogene, Src family tyrosine kinase
Symbols BLK ; MODY11
External IDs OMIM191305 MGI88169 HomoloGene1297 ChEMBL: 2250 GeneCards: BLK Gene
EC number
RNA expression pattern
PBB GE BLK 206255 at tn.png
More reference expression data
Species Human Mouse
Entrez 640 12143
Ensembl ENSG00000136573 ENSMUSG00000014453
UniProt P51451 P16277
RefSeq (mRNA) NM_001715 NM_007549
RefSeq (protein) NP_001706 NP_031575
Location (UCSC) Chr 8:
11.49 – 11.56 Mb
Chr 14:
63.37 – 63.42 Mb
PubMed search [1] [2]

Tyrosine-protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene.[1][2]


The tyrosine-protein kinase BLK has been shown to interact with UBE3A.[3]


  1. ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene 10 (3): 477–86. PMID 7845672. 
  2. ^ "Entrez Gene: BLK B lymphoid tyrosine kinase". 
  3. ^ Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731. 

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